7,25-dihydroxycholesterol-d6 700078P-1MG

Empirical Formula (Hill Notation):	C27H40D6O3
CAS Number:	2260669-11-0
Molecular Weight:	424.69
NACRES:	NA.25

7α,25-dihydroxycholesterol (7α,25-OHC) is synthesized by the hydroxylation of cholesterol by the action of enzyme cholesterol 25-hydroxylase (CH25H) and cytochrome P450, family 7, subfamily b, polypeptide 1 (CYP7B1). The catabolic breakdown of 7α,25-OHC to bile acid precursors is catalyzed by the enzymes hydroxy-Δ-5-steroid dehydrogenase, 3β- and steroid Δ-isomerase 7 (HSD3B7). 7α,25-dihydroxycholesterol-d6 is the deuterated form of 7α,25-dihydroxycholesterol.
7α,25-dihydroxycholesterol-d6 has be used as an internal standard in liquid chromatography electrospray ionization tandem mass spectrometric (LC–ESI-MS/MS) analysis of human plasma.
7α,25-dihydroxycholesterol (7α,25-OHC) serves as an endogenous ligand for G-protein-coupled receptor 183 (GPR183) or Epstein-Barr virus-induced gene 2 (EBI2). It plays a key role in the migration of type 3 innate lymphoid cells (ILC3) in the small intestine and colon. 7α,25-OHC mediates immune cell migration functionality by their chemoattractant property. Inhibition of 7α,25-OHC synthesis leads to impairment in the migration of B cells.
5 mL Amber Glass Screw Cap Vial (700078P-1mg)

assay	>99% (TLC)
form	powder
packaging	pkg of 1 x 1 mg (700078P-1mg)
Торговая марка	Avanti Polar Lipids
shipped in	dry ice
storage temp.	−20°C
SMILES string	[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(O)(C([2H])([2H])[2H])C([2H])([2H])[2H]

RIDADR	NONH for all modes of transport
Flash Point F	No data available
Flash Point C	No data available