Empirical Formula (Hill Notation): | C6H19NSi2 |
Linear Formula: | (CH3)3SiNHSi(CH3)3 |
CAS Number: | 999-97-3 |
Molecular Weight: | 161.39 |
Beilstein/REAXYS Number: | 635752 |
EC Number: | 213-668-5 |
MDL number: | MFCD00008259 |
PubChem Substance ID: | 329757861 |
Кат. номер |
52619-1ML |
52619-VAR |
52619-1L |
52619-10X1ML |
52619-250ML |
52619-50ML |
52619-10ML |
52619-6X250ML |
Hexamethyldisilazane (HMDS) is a commercially available, silylating agent, which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.
Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.
Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.
It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites, phenol, hydroquinone and catechol in urine samples, mixtures of free fatty acids and metal soaps in paint samples using gas chromatography/mass spectrometry (GC/MS).
Learn more in the Product Information
- HMDS is inexpensive and has a relatively low boiling point (124-127 °C).
- It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts.
- The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.
Important silylating agent
Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Quality Level | 100 |
grade | for GC derivatization |
assay | 99.0% (GC) |
quality | LiChropur™ |
reaction suitability | reagent type: derivatization reagent reaction type: Silylations |
application(s) | gas chromatography (GC): suitable |
refractive index | n20/D 1.407 (lit.), n20/D 1.408 |
bp | 125 °C (lit.) |
SMILES string | C[Si](C)(C)N[Si](C)(C)C |
InChI | 1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3 |
InChI key | FFUAGWLWBBFQJT-UHFFFAOYSA-N |
pictograms | GHS02,GHS05,GHS06 |
signalword | Danger |
hcodes | H225 - H302 + H332 - H311 - H314 - H412 |
pcodes | P210 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
Personal Protective Equipment | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter |
RIDADR | UN 1992 6.1(3) / PGII |
WGK Germany | WGK 2 |
Flash Point F | 52.5 °F - closed cup |
Flash Point C | 11.4 °C - closed cup |