Crosslinkers
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SBAP (succinimidyl 3-(bromoacetamido)propionate) 803650-50MG
Empirical Formula (Hill Notation): C9H11N2O5Br Molecular Weight: 307.10 MDL number: MFCD01863457 PubChem Substance ID: 329768824 NACRES: NA.22 General descriptionSBAP is a sulfhydryl-reactive and amine-reactive heterobifunctional crosslinker. The reagents NHS ester reacts with primary amines at pH 7-9 to form stable amide bonds, and the bromacetyl reacts with sulfhydryl groups at pH >7.5 to form stable thioether bonds This reagent is useful for preparing cyclic peptides and peptide conjugates because the spacer maintains peptide-like character in the crosslinked species.
Features and Benefits- Reactive groups: NHS ester and bromoacetyl
- Reactive toward: amino and sulfhydryl groups
- NHS ester reacts with primary amines at pH 7-9 to form a stable amide bond
- Bromacetyl group reacts with sulfhydryl groups at pH > 7.5 to form stable thioether bonds
- Non-cleavable
- Water-insoluble (dissolve first in DMF or DMSO)
- Spacer maintains peptide-like character in the crosslinked species
- Resulting crosslink is susceptible to acid hydrolysis
- Useful for preparing cyclic peptides and peptide conjugates
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 307.1 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(CCC1=O)N1OC(CCNC(CBr)=O)=O InChI 1S/C9H11BrN2O5/c10-5-6(13)11-4-3-9(16)17-12-7(14)1-2-8(12)15/h1-5H2,(H,11,13) InChI key WGMMKWFUXPMTRW-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SDA (NHS-Diazirine) (succinimidyl 4,4-azipentanoate) 803413-50MG
Empirical Formula (Hill Notation): C9H11N3O4 Molecular Weight: 225.20 MDL number: MFCD28899672 PubChem Substance ID: 329768804 NACRES: NA.22 General descriptionSuccinimidyl-diazirine (SDA) reagents are a new class of crosslinkers that combine proven amine-reactive chemistry with an innovative and efficient diazirine-based photochemistry for conjugating amine-containing molecules to nearly any other functional group. The SDA crosslinkers include six compounds differing in spacer arm lengths, ability to cleave the crosslinked proteins, and presence or absence of a charged group for membrane permeability. Protein crosslinking is an important technique used to understand protein structure and to stabilize protein-protein interactions, and these SDA reagents extend the efficiency and range of interactions that can be explored by this approach.
Features and Benefits- Membrane-permeable—suitable for in vivo intracellular protein crosslinking
- Heterobifunctional—NHS ester group reacts with primary amines at pH 7 to 9 to form covalent amide bonds; diazirine (azipentanoate) group reacts efficiently with any amino acid side chain or peptide backbone upon activation with long-wave UV light (330-370 nm)
- Controllable—two-step chemical crosslinking is activated using common laboratory UV lamps
- Easy to use—these crosslinkers are photo-stable under typical laboratory lighting conditions so there is no need to perform experiments in the dark
- Better than aryl azides—the diazirine photoreactive group has better photostability in normal light than phenyl azide groups of traditional photoreactive crosslinkers, yet the diazirine group is more efficiently activated by long-wave UV light
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 225.2 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string CC1(N=N1)CCC(ON2C(CCC2=O)=O)=O InChI 1S/C9H11N3O4/c1-9(10-11-9)5-4-8(15)16-12-6(13)2-3-7(12)14/h2-5H2,1H3 InChI key SYYLQNPWAPHRFV-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SIAB (N-succinimidyl (4-iodoacetyl)aminobenzoate) 803669-50MG
Empirical Formula (Hill Notation): C13H11N2O5I CAS Number: 72252-96-1 Molecular Weight: 402.14 MDL number: MFCD00054976 PubChem Substance ID: 329768825 NACRES: NA.22 General descriptionSIAB is an amine- and sulfhydryl-reactive heterobifunctional crosslinker and Sulfo-SIAB is its water-soluble analog. These crosslinkers contain an amine-reactive N-hydroxysuccimide (NHS) ester and a sulfhydryl-reactive iodoacetyl group, and are often used for preparing enzyme conjugates or immunotoxins. Water-soluble and water-insoluble forms of NHS esters have essentially identical reactivity. Sulfo-SIAB is supplied as a sodium salt and is water-soluble to ~10mM. SIAB must be first dissolved in an organic solvent, such as DMSO or DMF, and then added to the aqueous reaction mixture. SIAB is lipophilic, membrane-permeable and does not possess a charged group.
Features and Benefits- Reactive groups: NHS ester and iodoacetyl
- Reactive toward: amino and sulfhydryl groups
- Non-cleavable
- Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-SIAB
- Used to prepare stable enzyme-IgG conjugates
- Forms conjugates with liposomes
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥95% form powder mol wt 402.15 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(CCC1=O)N1OC(C2=CC=C(NC(CI)=O)C=C2)=O InChI 1S/C13H11IN2O5/c14-7-10(17)15-9-3-1-8(2-4-9)13(20)21-16-11(18)5-6-12(16)19/h1-4H,5-7H2,(H,15,17) InChI key BQWBEDSJTMWJAE-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SM(PEG)24 (PEGylated, long-chain SMCC crosslinker) 803391-100MG
Empirical Formula (Hill Notation): C62H111N3O31 NACRES: NA.22 General descriptionSM(PEG)n NHS- and maleimide-activated PEG compounds for crosslinking between primary amines (NH2) and sulfhydryl (SH) groups in proteins and other molecules. A complete set of compounds are offered, each having the same heterobifunctional structure (NHS-PEGn-Maleimide) but differing in the number of discrete ethylene glycol units ( n = 2, 4, 6, 8, 12 or 24). The N-hydroxysuccinimide ester (NHS) group reacts specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds. The maleimide group reacts with reduced sulfhydryls at pH 6.5-7.5 to form stable thioether bondsApplicationSM(PEG)24 can be used as a crosslinker in:- The study of chemical cross-linking of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and RNAses using the high-mass MALDI-MS technique.
- Preparation of protein G-liposomal nanovesicles applicable as sensors in the detection of gentamycin in the milk sample.
- Conjugation of catalase to streptavidin, which is helpful in the detection of analytes at very low concentrations using ELISA technique.
Features and Benefits- Reactive groups: NHS ester and maleimide
- Reactive toward: amino and sulfhydryl groups
- Irreversibly crosslink proteins or peptides by flexible PEG spacer arms
- Polyethylene glycol spacer arms help maintain conjugate solubility
- Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
- PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
- Ideal for performing controlled, two-step protein conjugations (see Sulfo-SMCC)
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыform powder Quality Level 100, mol wt 1394.55 reaction suitability reagent type: cross-linking reagent storage condition desiccated shipped in ambient storage temp. −20°C SMILES string O=C(N1OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O)=O)CCC1=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SMPH (succinimidyl-6-((b-maleimidopropionamido)hexanoate) 803626-50MG
Empirical Formula (Hill Notation): C17H21N3O7 Molecular Weight: 379.36 MDL number: MFCD01863460 PubChem Substance ID: 329768822 General descriptionSMPH is a heterobifunctional crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while the maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values greater than 7.5. For these reasons, conjugation experiments involving this type of heterobifunctional crosslinker are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.
Features and Benefits- Reactive groups: NHS ester and maleimide
- Reactive towards: amino and sulfhydryl groups
- Slightly longer and more soluble than SMPB
- NHS ester reacts with primary amines at pH 7-9, forming a stable amide bond
- Maleimide reacts with -SH groups at pH 6.5-7.5, forming a stable thioether bond
- Non-cleavable
- Water-insoluble (dissolve first in DMF or DMSO)
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 379.36 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(CCCCCNC(CCN1C(C=CC1=O)=O)=O)ON2C(CCC2=O)=O InChI 1S/C17H21N3O7/c21-12(9-11-19-13(22)5-6-14(19)23)18-10-3-1-2-4-17(26)27-20-15(24)7-8-16(20)25/h5-6H,1-4,7-11H2,(H,18,21) InChI key WCMOHMXWOOBVMZ-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SMPT (4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene) 803472-50MG
Empirical Formula (Hill Notation): C18H20N2O2S2 CAS Number: 112241-19-7 Molecular Weight: 360.49 MDL number: MFCD00083161 PubChem Substance ID: 329768810 NACRES: NA.22 General descriptionSMPT is a heterobifunctional sulfhydryl- and amine-reactive cross-linker. SMPT is used often for conjugating a toxin molecule to a monoclonal antibody directed against a cell-surface antigen. These immunotoxins produced with SMPT are highly potent as the cleavable disulfide imparts increased cytotoxicity compared to conjugates without a cleavable bond, such as those produced with SPDP. Also, next to the pyridine-2-thione in the spacer arm are a benzene ring and a methyl group adjacent to a carbon that hinders the disulfide bond, allowing exceptional conjugate stability in vivo. SMPT has the added benefit of being more stable to hydrolysis in aqueous solutions than other NHS cross-linkers.
Features and Benefits- Reactive groups: NHS ester and pyridyldithiol
- Reactive towards: amino and sulfhydryl groups
- Cleavable with disulfide reducing agents
- Water-insoluble (dissolve first in DMF or DMSO)
- Contains a hindered disulfide bond; has formed immunotoxins with improved stability
- In vitro, an SMPT conjugate was as effective as conjugates formed with SPDP and 2-IT
- Compare to other varieties of SPDP-type reagents, including pegylated forms
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 388.46 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(ON1C(CCC1=O)=O)C2=CC=C(C(SSC3=CC=CC=N3)C)C=C2 InChI 1S/C18H16N2O4S2/c1-12(25-26-15-4-2-3-11-19-15)13-5-7-14(8-6-13)18(23)24-20-16(21)9-10-17(20)22/h2-8,11-12H,9-10H2,1H3 InChI key GKSPIZSKQWTXQG-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SPB (succinimidyl-[4-(psoralen-8-yloxy)]butyrate) 803545-50MG
Empirical Formula (Hill Notation): C19H15NO8 Molecular Weight: 385.32 PubChem Substance ID: 329768817 NACRES: NA.22 General descriptionSPB is an amine-reactive and photoreactive heterobifunctional crosslinking reagent. The photoreactive psoralen group provides much greater covalent insertion yields than phenyl azide-containing compounds, which makes this reagent a superior alternative to typical photoreactive NHS-ester crosslinkers. The psoralen tricyclic planar ring system intercalates into double-stranded, and to a lesser extent, single-stranded, DNA, RNA, PCR products, cDNA or oligonucleotides. It also can be used with agarose gel-purified oligonucleotides because the presence of agarose does not interfere with the coupling reaction. The nucleic acid labeling site of the psoralen group (the 5,6 double bond in thymine residues) does not interfere with subsequent hybridization reactions, creating a highly-sensitive direct labeling alternative to radioactive probes.
Features and Benefits- Reactive groups: NHS ester and psoralen
- Reactive toward: amino groups and thymine
- DNA intercalating agent and nucleic acid probe1,2
- Reagent for photo-immobilization to microplates3
- Melting point: 177-178°C
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыform powder Quality Level 100, mol wt 385.32 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility DMSO or DMF: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C1CCC(N1OC(CCCOC2=C(OC(C=C3)=O)C3=CC4=C2OC=C4)=O)=O InChI 1S/C19H15NO8/c21-13-4-5-14(22)20(13)28-16(24)2-1-8-25-19-17-12(7-9-26-17)10-11-3-6-15(23)27-18(11)19/h3,6-7,9-10H,1-2,4-5,8H2 InChI key ZOMXGWWLJXRQKZ-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport Узнать цену -
Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester) sodium salt
Empirical Formula (Hill Notation): C16H18N2Na2O14S2 CAS Number: 82436-77-9 Molecular Weight: 572.43 MDL number: MFCD00054982 PubChem Substance ID: 329824554
Кат. номер S5799-100MG-PW S5799-25MG S5799-100MG S5799-25MG-PW General descriptionSuberic acid bis(3-sulfo-N-hydroxysuccinimide ester) sodium salt (BS3) is a water soluble, homobifunctional cross-linking reagent with amine reactivity. It is typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). It incorporates 8-atom linker.ApplicationSuberic acid bis(3-sulfo-N-hydroxysuccinimide ester) sodium salt (BS3) is useful for the preparation of protein-protein, receptor-ligand and hapten carrier molecule conjugates.Packaging25 mg in poly bottle
100 mg in glass bottleПараметрыQuality Level 300 assay 95% (H-NMR) form powder reaction suitability reagent type: cross-linking reagent solubility H2O: 10 mg/mL, DMF: soluble storage temp. 20°C SMILES string [Na+].[Na+].[O-]S(=O)(=O)C1CC(=O)N(OC(=O)CCCCCCC(=O)ON2C(=O)CC(C2=O)S([O-])(=O)=O)C1=O InChI 1S/C16H20N2O14S2.2Na/c19-11-7-9(33(25,26)27)15(23)17(11)31-13(21)5-3-1-2-4-6-14(22)32-18-12(20)8-10(16(18)24)34(28,29)30;;/h9-10H,1-8H2,(H,25,26,27)(H,28,29,30);;/q;2*+1/p-2 InChI key MGJYOHMBGJPESL-UHFFFAOYSA-L
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Suberic acid bis(N-hydroxysuccinimide ester)
Empirical Formula (Hill Notation): C16H20N2O8 CAS Number: 68528-80-3 Molecular Weight: 368.34 MDL number: MFCD00049059 PubChem Substance ID: 24899500 NACRES: NA.21
Кат. номер S1885-1G S1885-5G S1885-500MG General descriptionSuberic acid bis(N-hydroxysuccinimide ester) is a homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). Suberic acid bis(N-hydroxysuccinimide ester) incorporates an 8-atom linker.ApplicationSuberic acid bis(N-hydroxysuccinimide ester) has been:- supplemented in pierce lysis buffer used for immunoprecipitation
- used to conjugate the oligonucleotide standards to gelatin
- used in cross-linking of ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomers
Packaging500 mg in poly bottle
1, 5 g in poly bottleПараметрыQuality Level 200 assay ≥95% form powder reaction suitability reagent type: cross-linking reagent solubility chloroform: 50 mg/mL, DMF: soluble, aqueous buffer: slightly soluble (may require 5-10% organic solvent in coupling mixture.) storage temp. 2-8°C SMILES string O=C(CCCCCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O InChI 1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2 InChI key ZWIBGKZDAWNIFC-UHFFFAOYSA-N
Safety InformationPersonal Protective Equipment Eyeshields, Gloves, type N95 (US) RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Sulfo-EGS (ethylene glycol bis(sulfosuccinimidyl succinate)) 803219-50MG
Empirical Formula (Hill Notation): C18H18O18N2Na2S2 Molecular Weight: 660.45 MDL number: MFCD00054988 PubChem Substance ID: 329768789 NACRES: NA.22 General descriptionEGS is a water-insoluble, homobifunctional N-hydroxysuccinimide ester (NHS ester) and Sulfo-EGS is its water-soluble analog. The spacer arm contains two cleavable ester sites that may be broken with hydroxylamine, which yields two fragments with terminal amide bonds and the release of ethylene glycol. These reagents are often used for conjugating radiolabeled ligands to cell surface receptors. The water insoluble reagent EGS does not possess a charged group, is lipophilic and, therefore, membrane-permeable and useful for intracellular and intramembrane protein conjugation. EGS is first dissolved in DMSO or DMF and added to the aqueous reaction mixture at a final solvent concentration of 10-20%, to minimize detrimental affects to the protein.
Features and Benefits- Reactive groups: sulfo-NHS ester (both ends)
- Reactive towards: amino groups (primary amines)
- Water-soluble; compare to EGS
- Membrane-impermeable, allowing for cell surface labeling
- Crosslinks formed are reversible at pH 8.5 using hydroxylamine for 3 to 6 hours at 37°C
- Lactose dehydrogenase retained 60% of its activity after reversible crosslinking with EGS
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыform powder Quality Level 100, mol wt 660.45 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. −20°C InChI 1S/C18H20N2O18S2.2Na/c21-11-7-9(39(29,30)31)17(27)19(11)37-15(25)3-1-13(23)35-5-6-36-14(24)2-4-16(26)38-20-12(22)8-10(18(20)28)40(32,33)34;;/h9-10H,1-8H2,(H,29,30,31)(H,32,33,34);;/q;2*+1/p-2 InChI key IYBKWXQWKPSYDT-UHFFFAOYSA-L
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Sulfo-EMCS (N-(-maleimidocaproyloxy) sulfosuccinimide ester) 803235-50MG
Empirical Formula (Hill Notation): C14H13O9SN2Na Molecular Weight: 408.32 MDL number: MFCD09953186 PubChem Substance ID: 329768791 NACRES: NA.22 General descriptionEMCS and its water-soluble analog Sulfo-EMCS are heterobifunctional cross-linkers that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugation experiments involving these cross-linkers are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.
Features and Benefits- Reactive groups: sulfo-NHS ester and maleimide
- Reactive towards: amino and sulfhydryl groups
- Sulfo-NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
- Maleimide reacts with -SH groups at pH 6.5-7.5, forming stable thioether linkages
- Non-cleavable
- Water-soluble (compare to EMCS)
- Aliphatic spacer offers low potential for eliciting an immune response
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыform powder Quality Level 100, mol wt 410.33 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C1CC(S(=O)([O-])=O)C(N1OC(CCCCCN2C(C=CC2=O)=O)=O)=O.[Na+] InChI 1S/C14H16N2O9S.Na/c17-10-5-6-11(18)15(10)7-3-1-2-4-13(20)25-16-12(19)8-9(14(16)21)26(22,23)24;/h5-6,9H,1-4,7-8H2,(H,22,23,24);/q;+1/p-1 InChI key MIDXXTLMKGZDPV-UHFFFAOYSA-M
Safety InformationRIDADR NONH for all modes of transport Узнать цену -
Sulfo-LC-SDA (Sulfo-NHS-LC-Diazirine) (sulfosuccinimidyl 6-(4,4-azipentanamido)hexanoate) 803359-50MG
Empirical Formula (Hill Notation): C15H21N4NaO8S Molecular Weight: 440.40 MDL number: MFCD28899432 PubChem Substance ID: 329768799 NACRES: NA.22 General descriptionSuccinimidyl-diazirine (SDA) reagents are a new class of crosslinkers that combine proven amine-reactive chemistry with an innovative and efficient diazirine-based photochemistry for conjugating amine-containing molecules to nearly any other functional group. The SDA crosslinkers include six compounds differing in spacer arm lengths, ability to cleave the crosslinked proteins, and presence or absence of a charged group for membrane permeability. Protein crosslinking is an important technique used to understand protein structure and to stabilize protein-protein interactions, and these SDA reagents extend the efficiency and range of interactions that can be explored by this approach.
Features and Benefits- Water soluble—solubility in aqueous solutions improved by a sulfonate group
- Heterobifunctional—NHS ester group reacts with primary amines at pH 7 to 9 to form covalent amide bonds; diazirine (azipentanoate) group reacts efficiently with any amino acid side chain or peptide backbone upon activation with long-wave UV light (330-370 nm)
- Controllable—two-step chemical crosslinking is activated using common laboratory UV lamps
- Easy to use—these crosslinkers are photo-stable under typical laboratory lighting conditions so there is no need to perform experiments in the dark
- Better than aryl azides—the diazirine photoreactive group has better photostability in normal light than phenyl azide groups of traditional photoreactive crosslinkers, yet the diazirine group is more efficiently activated by long-wave UV light
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 440.4 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(N1OC(CCCCCNC(CCC2(N=N2)C)=O)=O)CC(S(=O)([O-])=O)C1=O.[Na+] InChI 1S/C15H22N4O8S.Na/c1-15(17-18-15)7-6-11(20)16-8-4-2-3-5-13(22)27-19-12(21)9-10(14(19)23)28(24,25)26;/h10H,2-9H2,1H3,(H,16,20)(H,24,25,26);/q;+1/p-1 InChI key NZJSKWCJBUEDEO-UHFFFAOYSA-M
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Sulfo-LC-SPDP (sulfosuccinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate) 803316-50MG
Empirical Formula (Hill Notation): C14H16N3NaO8S3 Molecular Weight: 473.48 MDL number: MFCD00083162 PubChem Substance ID: 329768795 NACRES: NA.22 General descriptionThe SPDP reagents are a unique group of amine- and sulfhydryl-reactive heterobifunctional crosslinkers. Whether they are used to form amine-to-amine or amine-to-sulfhydryl crosslinks among molecules, the SPDP reagents produce disulfide-containing linkages that can be cleaved later with reducing agents such as dithiothreitol (DTT).
Features and Benefits- Reactive groups: NHS ester and pyridyldithiol
- Reactive towards: amino and sulfhydryl groups
- Releases a detectable by-product when reacted with a free sulfhydryl group; by measuring the release of pyridine-2-thione at 343 nm, the reaction can be easily followed
- Water soluble, sulfo-NHS ester reacts rapidly with any primary amine-containing molecule
- Disulfide bond in the spacer arm is readily cleaved by 10-50 mM DTT or TCEP at pH 8.5
- Spacer arm is also easily cleaved using reducing SDS-PAGE sample loading buffer
- Cleavable crosslinker allows separation of crosslinked products
- Sulfo-LC-SPDP crosslinker is not membrane permeable, allowing cell surface labeling
- Compare to other varieties of SPDP-type reagents, including pegylated forms
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 527.57 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility soluble (>95 mg/ml in water) shipped in ambient storage temp. −20°C SMILES string O=C1CC(S(=O)([O-])=O)C(N1OC(CCCCCNC(CCSSC2=CC=CC=N2)=O)=O)=O.[Na+] InChI 1S/C18H23N3O8S3.Na/c22-14(8-11-30-31-15-6-3-5-10-20-15)19-9-4-1-2-7-17(24)29-21-16(23)12-13(18(21)25)32(26,27)28;/h3,5-6,10,13H,1-2,4,7-9,11-12H2,(H,19,22)(H,26,27,28);/q;+1/p-1 InChI key ZAPNXDUFCQIHFS-UHFFFAOYSA-M
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Sulfo-MBS (m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester) 803227-50MG
Empirical Formula (Hill Notation): C15H9O9N2NaS Molecular Weight: 416.29 MDL number: MFCD00054983 PubChem Substance ID: 329768790 General descriptionMBS and its water-soluble analog Sulfo-MBS are heterobifunctional crosslinkers that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugation experiments involving these crosslinkers are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneously with the maleimide (sulfhydryl-targeted) reaction.
Features and Benefits- Reactive groups: sulfo-NHS ester and maleimide
- Reactive towards: amino and sulfhydryl groups
- Non-cleavable
- Water-soluble (compare to MBS)
- Membrane impermeable, allowing cell surface labeling
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыassay ≥80% Quality Level 100, form powder mol wt 416.3 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. −20°C SMILES string O=C(C1=CC(N2C(C=CC2=O)=O)=CC=C1)ON3C(C(S(=O)([O-])=O)CC3=O)=O.[Na+] InChI 1S/C15H10N2O9S.Na/c18-11-4-5-12(19)16(11)9-3-1-2-8(6-9)15(22)26-17-13(20)7-10(14(17)21)27(23,24)25;/h1-6,10H,7H2,(H,23,24,25);/q;+1/p-1 InChI key LKUULGDICDGFIQ-UHFFFAOYSA-M
Safety InformationRIDADR NONH for all modes of transport Узнать цену -
Sulfo-SANPAH (sulfosuccinimidyl 6-(4-azido-2-nitrophenylamino)hexanoate) 803332-50MG
Empirical Formula (Hill Notation): C16H17O9N6NaS Molecular Weight: 492.40 PubChem Substance ID: 329768797 NACRES: NA.22 General descriptionANB-NOS and Sulfo-SANPAH are heterobifunctional crosslinkers that contain an amine-reactive N-hydroxysuccinimide (NHS) ester and a photoactivatable nitrophenyl azide. NHS esters react efficiently with primary amino groups (-NH2) in pH 7-9 buffers to form stable amide bonds. When exposed to UV light nitrophenyl azides form a nitrene group that can initiate addition reactions with double bonds, insertion into C-H and N-H sites, or subsequent ring expansion to react with a nucleophile (e.g., primary amines).Features and Benefits- Reactive groups: sulfo-NHS ester and nitrophenyl azide
- Reactive towards: amino groups and any nucleophile
- Non-cleavable
- N-Sulfosuccinimidyl-6-(4-azido-2-nitrophenylamino) hexanoate
- Optimal photolysis occurs at 320-350 nm; minimizes damage to biomolecules by irradiation
- Water soluble; non-cleavable
CautionThis product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыform powder Quality Level 100 mol wt 492.4 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. −20°C SMILES string O=C1CC(S(=O)([O-])=O)C(N1OC(CCCCCNC2=CC=C(N=[N+]=[N-])C=C2[N+]([O-])=O)=O)=O.[Na+] InChI 1S/C16H18N6O9S.Na/c17-20-19-10-5-6-11(12(8-10)22(26)27)18-7-3-1-2-4-15(24)31-21-14(23)9-13(16(21)25)32(28,29)30;/h5-6,8,13,18H,1-4,7,9H2,(H,28,29,30);/q;+1/p-1 InChI key XXUXLXCHYVHAOD-UHFFFAOYSA-M
Safety Informationpictograms GHS07 signalword Warning hcodes H319 pcodes P264 - P280 - P305 + P351 + P338 - P337 + P313 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Sulfo-SDA (Sulfo-NHS-Diazirine) (sulfosuccinimidyl 4,4-azipentanoate) 803340-50MG
Empirical Formula (Hill Notation): C9H10N3Na7S Molecular Weight: 353.19 MDL number: MFCD28899433 PubChem Substance ID: 329768798 NACRES: NA.22 General descriptionSuccinimidyl-diazirine (SDA) reagents are a new class of crosslinkers that combine proven amine-reactive chemistry with an innovative and efficient diazirine-based photochemistry for conjugating amine-containing molecules to nearly any other functional group. The SDA crosslinkers include six compounds differing in spacer arm lengths, ability to cleave the crosslinked proteins, and presence or absence of a charged group for membrane permeability. Protein crosslinking is an important technique used to understand protein structure and to stabilize protein-protein interactions, and these SDA reagents extend the efficiency and range of interactions that can be explored by this approach.
Features and Benefits- Water soluble—solubility in aqueous solutions improved by a sulfonate group
- Heterobifunctional—NHS ester group reacts with primary amines at pH 7 to 9 to form covalent amide bonds; diazirine (azipentanoate) group reacts efficiently with any amino acid side chain or peptide backbone upon activation with long-wave UV light (330-370 nm)
- Controllable—two-step chemical crosslinking is activated using common laboratory UV lamps
- Easy to use—these crosslinkers are photo-stable under typical laboratory lighting conditions so there is no need to perform experiments in the dark
- Better than aryl azides—the diazirine photoreactive group has better photostability in normal light than phenyl azide groups of traditional photoreactive crosslinkers, yet the diazirine group is more efficiently activated by long-wave UV light
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.ПараметрыQuality Level 100, assay ≥90% form powder mol wt 327.25 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. 2-8°C SMILES string O=C(C(S(=O)([O-])=O)C1)N(OC(CCC2(N=N2)C)=O)C1=O.[Na+] InChI 1S/C9H11N3O7S.Na/c1-9(10-11-9)3-2-7(14)19-12-6(13)4-5(8(12)15)20(16,17)18;/h5H,2-4H2,1H3,(H,16,17,18);/q;+1/p-1 InChI key KTYCFZFVXSHAGH-UHFFFAOYSA-M
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Sulfo-SDAD (Sulfo-NHS-SS-Diazirine) (sulfosuccinimidyl 2-[(4,4-azipentanamido)ethyl]-1,3-dithiopropionate] 803367-50MG
Empirical Formula (Hill Notation): C14H19N4NaO8S3 Molecular Weight: 490.51 MDL number: MFCD28899434 PubChem Substance ID: 329768800 NACRES: NA.22 General descriptionSuccinimidyl-diazirine (SDA) reagents are a new class of crosslinkers that combine proven amine-reactive chemistry with an innovative and efficient diazirine-based photochemistry for conjugating amine-containing molecules to nearly any other functional group. The SDA crosslinkers include six compounds differing in spacer arm lengths, ability to cleave the crosslinked proteins, and presence or absence of a charged group for membrane permeability. Protein crosslinking is an important technique used to understand protein structure and to stabilize protein-protein interactions, and these SDA reagents extend the efficiency and range of interactions that can be explored by this approach.
Features and Benefits- Water soluble—solubility in aqueous solutions improved by a sulfonate group
- Heterobifunctional—NHS ester group reacts with primary amines at pH 7 to 9 to form covalent amide bonds; diazirine (azipentanoate) group reacts efficiently with any amino acid side chain or peptide backbone upon activation with long-wave UV light (330-370 nm)
- Controllable—two-step chemical crosslinking is activated using common laboratory UV lamps
- Easy to use—these crosslinkers are photo-stable under typical laboratory lighting conditions so there is no need to perform experiments in the dark
- Better than aryl azides—the diazirine photoreactive group has better photostability in normal light than phenyl azide groups of traditional photoreactive crosslinkers, yet the diazirine group is more efficiently activated by long-wave UV light
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыassay ≥80% Quality Level 100, form powder mol wt 490.51 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. 2-8°C SMILES string CC1(N=N1)CCC(NCCSSCCC(ON2C(C(S([O-])(=O)=O)CC2=O)=O)=O)=O.[Na+] InChI 1S/C14H20N4O8S3.Na/c1-14(16-17-14)4-2-10(19)15-5-7-28-27-6-3-12(21)26-18-11(20)8-9(13(18)22)29(23,24)25;/h9H,2-8H2,1H3,(H,15,19)(H,23,24,25);/q;+1/p-1 InChI key BTBHSSBEJHAIAF-UHFFFAOYSA-M
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Sulfo-SIAB (sulfosuccinimidyl (4-iodoacetyl)aminobenzoate) 803324-50MG
Empirical Formula (Hill Notation): C13H10O8N2SINa Molecular Weight: 504.19 MDL number: MFCD00054977 PubChem Substance ID: 329768796 NACRES: NA.22 General descriptionSIAB is an amine- and sulfhydryl-reactive heterobifunctional crosslinker and Sulfo-SIAB is its water-soluble analog. These crosslinkers contain an amine-reactive N-hydroxysuccimide (NHS) ester and a sulfhyryl-reactive iodoacetyl group, and are often used for preparing enzyme conjugates or immunotoxins. Water-soluble and water-insoluble forms of NHS esters have essentially identical reactivity. Sulfo-SIAB is supplied as a sodium salt and is water-soluble to ~10mM. SIAB must be first dissolved in an organic solvent, such as DMSO or DMF, and then added to the aqueous reaction mixture. SIAB is lipophilic, membrane-permeable and does not possess a charged group.
Features and Benefits- Reactive groups: sulfo-NHS ester and iodoacetyl
- Reactive toward: amino and sulfhydryl groups
- Non-cleavable
- Water-soluble (compare to SIAB)
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыform powder Quality Level 100, mol wt 504.2 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. −20°C SMILES string O=C1CC(S(=O)([O-])=O)C(N1OC(C2=CC=C(NC(CI)=O)C=C2)=O)=O.[Na+] InChI 1S/C13H11IN2O8S.Na/c14-6-10(17)15-8-3-1-7(2-4-8)13(20)24-16-11(18)5-9(12(16)19)25(21,22)23;/h1-4,9H,5-6H2,(H,15,17)(H,21,22,23);/q;+1/p-1 InChI key HHSGWIABCIVPJT-UHFFFAOYSA-M
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate) 803243-50MG
Empirical Formula (Hill Notation): C18H15N2O9SNa Molecular Weight: 458.37 MDL number: MFCD00054981 PubChem Substance ID: 329768792 NACRES: NA.22 General descriptionSMPB and its water-soluble analog Sulfo-SMPB are heterobifunctional crosslinkers that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugation experiments involving these crosslinkers are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.
Features and Benefits- Reactive groups: sulfo-NHS ester and maleimide
- Reactive towards: amino and sulfhydryl groups
- Extended chain length limits steric hindrance
- Non-cleavable
- Water-soluble (compare to SMPB)
- Membrane impermeable, allowing for cell surface labeling
Caution
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.Параметрыform powder Quality Level 100, mol wt 458.38 reaction suitability reagent type: cross-linking reagent storage condition desiccated solubility water: soluble shipped in ambient storage temp. −20°C SMILES string O=C1CC(S(=O)([O-])=O)C(N1OC(CCCC2=CC=C(N3C(C=CC3=O)=O)C=C2)=O)=O.[Na+] InChI 1S/C18H16N2O9S.Na/c21-14-8-9-15(22)19(14)12-6-4-11(5-7-12)2-1-3-17(24)29-20-16(23)10-13(18(20)25)30(26,27)28;/h4-9,13H,1-3,10H2,(H,26,27,28);/q;+1/p-1 InChI key LSZBIKKARBHBPA-UHFFFAOYSA-M
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
t-Boc-N-amido-PEG1-CH2CO2H 901579-50MG
Empirical Formula (Hill Notation): C9H17NO5 CAS Number: 142929-49-5 Molecular Weight: 219.23 MDL number: MFCD09909935 NACRES: NA.22 ApplicationThis is a crosslinker with a t-Boc protected amine on one end and a carboxyl group on the other end. The compound contains a single PEG unit to help improve solubility
t-Boc-N-amido-PEG1-CH2CO2H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG1-CH2CO2H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation,.Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыform liquid reaction suitability reagent type: cross-linking reagent storage temp. 20°C SMILES string O=C(O)COCCNC(OC(C)(C)C)=O, O=C(O)COCCNC(OC(C)(C)C)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
Urea crosslinker – C2-arm, NHS ester CF0039-50MG
Linear Formula: C13H14N4O9 CAS Number: 211029-82-2 MDL number: MFCD31618503 ApplicationThe ureido-2,2-diacetic acid bis(hydroxysuccinimide) ester, is the shortest version of MS-cleavable urea-based lysine-lysine reactive homobifunctional cross-linkers, featuring a C2-arm. At neutral or slightly basic pH, it irreversibly crosslinks the neighbouring lysine groups. The presence of the symmetrical urea moiety which is prone to collision-induced dissociation, allows for the unambiguous distinguishing of crosslinks in tandem CID-MS experiments.Legal InformationProduct of CF Plus Chemicals.Параметрыform solid reaction suitability reagent type: cross-linking reagent
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Urea crosslinker – C3-arm, NHS ester CF0040-50MG
Linear Formula: C15H18N4O9 CAS Number: 2185840-20-2 MDL number: MFCD31618504 ApplicationThe ureido-3,3-dipropionic acid bis(hydroxysuccinimide) ester, is a medium length MS-cleavable urea-based lysine-lysine reactive homobifunctional cross-linkers, featuring a C3-arm. At neutral or slightly basic pH, it irreversibly crosslinks the neighbouring lysine groups. The presence of the symmetrical urea moiety which is prone to collision-induced dissociation allows for the unambiguous distinguishing of crosslinks in tandem CID-MS experiments.Legal InformationProduct of CF Plus Chemicals.Параметрыform solid reaction suitability reagent type: cross-linking reagent
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Urea crosslinker – C4-arm, NHS ester (DSBU, BuUrBU) CF0041-50MG
Linear Formula: C17H22N4O9 CAS Number: 1240387-33-0 MDL number: MFCD30738322 ApplicationThe ureido-4,4-dibutyric acid bis(hydroxysuccinimide) ester, also known as DSBU or BuUrBU, is the longest version of MS-cleavable urea-based lysine-lysine reactive homobifunctional cross-linkers, featuring a C4-arm. At neutral or slightly basic pH, it irreversibly crosslinks the neighbouring lysine groups. The presence of the symmetrical urea moiety which is prone to collision-induced dissociation allows for the unambiguous distinguishing of crosslinks in tandem CID-MS experiments.Legal InformationProduct of CF Plus Chemicals.Параметрыform solid reaction suitability reagent type: cross-linking reagent
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену
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С 2010 года мы поставляем оборудование с заводов Европы. Берем на себя все — от подбора оборудования до внедрения на предприятии
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