Anti-Dysbindin antibody produced in rabbit SAB4200409-200UL

NACRES:

NA.41

Dysbindin (also known as DTNBP1) is a neuronal protein. DTNBP1 mRNA is widely expressed in the brain, located in postsynaptic densities and synaptic vesicles of neurons. Dysbindin-1 is coded by dystrobrevin-binding protein 1 gene (DTNBP1), that is located on the short (p) arm of human chromosome 6.
synthetic peptide corresponding to a sequence at an internal region of human dysbindin, conjugated to KLH. The corresponding sequence is identical in human dysbindin isoforms b, c and in rat and mouse dysbindin.
Anti-Dysbindin antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Dysbindin (DTNBP1) controls synaptic homeostasis by regulating the exocytosis and formation of synaptic vesicles. The DTNBP1 gene has been linked to schizophrenia in humans. Polymorphism of DTNBP1 confers susceptibility to schizophrenia through a decreased expression of dysbindin. Mutations in the human DTNBP1 gene causes a novel form of Hermansky-Pudlak syndrome (HPS) called HPS-7, a genetically heterogeneous disorder caused by abnormal vesicle trafficking to lysosomes and related organelles. Dysbindin, a constituent of the biogenesis of lysosome-related organelles complex 1 (BLOC-1), controls the trafficking of proteins in the lysosomal pathway, suggesting that dysbindin has a role in the biogenesis of lysosome-related organelles.
Physical form
Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
Quality Level	200
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen ~60 kDa
species reactivity	human, mouse, rat
enhanced validation	recombinant expression
concentration	~1.0 mg/mL
application(s)	indirect immunofluorescence: 5-10 µg/mL using PC12 cells.","western blot: 1-2 µg/mL using HEK-293T cells overexpressing human dysbindin.
conjugate	unconjugated
UniProt accession no.	Q96EV8,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... DTNBP1(84062) mouse ... Dtnbp1(94245) rat ... Dtnbp1(641528)

RIDADR	NONH for all modes of transport
Flash Point F	Not applicable
Flash Point C	Not applicable