Anti-NAV3 (N-terminal) antibody produced in rabbit

NACRES:

NA.41

Кат. номер

N4038-25UL

N4038-200UL

NAV3 (neuron navigator 3, also known as unc-53H3, steerin3, POMFIL1) belongs to the neuron navigator (NAV) family of proteins. NAV proteins are predominantly expressed in the nervous system. NAV3 expression is detected in brain.
NAV3 is made up of a calponin homology (CH) domain, a cytoskeletal interacting domain (CSID), four coiled-coil (CC) domains, and an AAA-domain.
Neuron navigator 3 (NAV3) is highly expressed in tumors. It possesses actin-binding domains and the gene encoding it is localized on chromosome 12q21.
Specificity
Anti-NAV3 (N-terminal) specifically recognizes human NAV3.
Biochem/physiol Actions
NAV3 (neuron navigator 3) has been suggested to function as a novel tumor suppressor gene. It is a putative haploin sufficient tumor suppressor gene, which helps in the growth, differentiation and apoptosis of cutaneous T-cell lymphoma (CTCL)cells.
NAV3 gene deletions and translocation affect patients with advanced mycosis fungoides or Sezary syndrome, the most common forms of primary cutaneous T-cell lymphoma (CTCL), suggesting that it may provide a novel diagnostic tool.
Neuron navigator 3 (NAV3) has been shown to control migration and invasion of epithelial cells. Once it is activated by growth factors, NAV3 occupies the ends of microtubules and stimulates their growth.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
Quality Level	200
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen ~280 kDa
species reactivity	human, rat (predicted), mouse (predicted)
packaging	antibody small pack of 25 µL
enhanced validation	recombinant expression
concentration	~1 mg/mL
application(s)	western blot: 1-2 µg/mL using HEK-293T cells lysate expressing human NAV3 fusion protein
conjugate	unconjugated
UniProt accession no.	Q8IVL0,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... NAV3(89795) mouse ... Nav3(260315) rat ... Nav3(314814)

Personal Protective Equipment	Eyeshields,, Gloves,, multi-purpose combination respirator cartridge (US),
RIDADR	NONH for all modes of transport
Flash Point F	Not applicable
Flash Point C	Not applicable