Anti-PGC-1(N-terminal) antibody produced in rabbit SAB4200226-200UL

MDL number:	MFCD03097133
NACRES:	NA.41

PPARG coactivator 1 α (PPARGC1A), a master transcriptional coactivator is a 91kDa multifunctional regulatory factor, encoded by the gene mapped to human chromosome 4p15.1. The encoded protein is mainly expressed in heart, skeletal muscle and kidney.
Anti-PGC-1α(N-terminal) antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
PPARG coactivator 1 α (PPARGC1α) integrates and regulates several metabolic pathways in response to external stimuli. PGC-1α regulates adaptive thermogenesis in brown adipose tissue and insulin signaling in skeletal muscle by activation of central metabolic and energy-related genes. It has a central role in the regulation of liver gluconeogenesis, β-oxidation of fatty acids and ketogenesis, by coactivation of key enzymes in the metabolic pathway, indicating that PGC-1α plays an important role as a global regulator of liver metabolism during fasting. PGC-1a is also a potent activator of mitochondrial biogenesis by coactivation of estrogen related receptor α(ERRα), nuclear respiratory factors (NRF)-1 and NRF-2. PGC-1a has been shown to suppress the generation of reactive oxygen species (ROS) and neurodegeneration by protecting neuronal cells from oxidative stress-mediated death. PGC-1α has been recently proposed to control muscle plasticity, to suppress broad inflammatory response and mediate the beneficial aspects of exercise.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
Quality Level	200
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen ~120 kDa
species reactivity	human
enhanced validation	recombinant expression recombinant expression
concentration	~1.0 mg/mL
application(s)	western blot: 1-2 µg/mL using HEK293-T cells expressing human PGC-1
conjugate	unconjugated
UniProt accession no.	Q9UBK2,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... PPARGC1A(10891)

RIDADR	NONH for all modes of transport
Flash Point F	Not applicable
Flash Point C	Not applicable