Anti-SORBS2 (N-terminal) antibody produced in rabbit

NACRES:

NA.44

Кат. номер

SAB4200038-25UL

SAB4200038-200UL

SORBS2 (also known as ArgBP2), is an Arg/Abl (proto-oncogene 1, non-receptor tyrosine kinase)-binding protein, that contains an N-terminal sorbin homology (SoHo) domain which interacts with lipid raft proteins, three C-terminal SH3 domains, a Ser/Thr-rich domain, and several potential Abl phosphorylation sites. SORBS2 associates with and is a substrate of Arg and v-Abl. The human SORBS2 gene encodes multiple transcripts that yield different isoforms. SORBS2 is ubiquitously expressed in human tissues and predominant in heart and epithelial cells. SORBS2 is also found in stress fibers and in the nucleus. In cardiac muscle cells, SORBS2 is in the Z-disks of sarcomeres.
Anti-SORBS2 (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Sorbin and SH3 domain containing 2 (SORBS2) might function as an adapter protein to assemble signaling complexes in stress fibers and is a potential link between Abl kinases and the actin cytoskeleton.
Physical form
Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen ~85 kDa
species reactivity	human
packaging	antibody small pack of 25 µL
enhanced validation	recombinant expression
concentration	~1.5 mg/mL
application(s)	indirect immunofluorescence: 20-40 µg/mL using HeLa cells","western blot: 0.2-0.4 µg/mL using HEK-293T cell lysates expressing human SORBS2
conjugate	unconjugated
UniProt accession no.	O94875,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... SORBS2(8470)

RIDADR	NONH for all modes of transport
Flash Point F	Not applicable
Flash Point C	Not applicable