Anti-Synapsin II (C-terminal) antibody produced in rabbit

NACRES:

NA.41

Кат. номер

S2947-25UL

S2947-200UL

Synapsins are a family of neuron-specific phosphoproteins that are localized on the cytoplasmic surface of small synaptic vesicles. Synapsins are ubiquitously expressed in neurons. The synapsin 2 (Syn2) gene is located on human chromosome 3p25. It belongs to the neuronal phosphoprotein family.
Specificity
Anti-Synapsin II(C-terminal) specifically recognizes human, rat and mousesynapsin II.
synthetic peptide corresponding to amino acids 569-586 of rat synapsin IIa isoform, conjugated to KLH. This sequence is identical in rat synapsin IIa, human synapsin IIa, and mouse synapsin II, and is not found in rat and human synapsin IIb.
Anti-Synapsin II (C-terminal) antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
Synapsins regulate synaptic vesicle clustering and the formation of synaptic terminals. Synapsin II (Syn2) is involved in the formation of synaptic terminals during neuronal development. It can link synaptic vesicles to the actin cytoskeleton, thus regulating the availability of synaptic vesicles for exocytosis. Synapsin II association with synaptic vesicles is controlled by phosphorylation. It is proposed as a candidate associated with increased vulnerability to schizophrenia. It plays an important role in synaptogenesis and neurotransmitter release. Syn2 also helps to locate nitric oxide synthase to the vicinity of its targets.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slightturbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
Quality Level	200
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen ~74 kDa (synapsin IIa)
species reactivity	mouse, human, rat
packaging	antibody small pack of 25 µL
enhanced validation	recombinant expression
concentration	~1.5 mg/mL
application(s)	western blot: 0.25-0/5 µg/mL using extracts of HEK-293T cells expressing human synapsin II, mouse brain extract (S1 fraction), and rat PC12 cell lysate
conjugate	unconjugated
UniProt accession no.	Q92777,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... SYN2(6854) mouse ... Syn2(20965) rat ... Syn2(29179)

Personal Protective Equipment	Eyeshields,, Gloves,, multi-purpose combination respirator cartridge (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable