Anti-Synaptotagmin 7 (C-terminal) antibody produced in rabbit SAB4200308-200UL

NACRES:

NA.41

Synaptotagmin7 (SYT7) belongs to the synaptotagmin gene family. It codes for and encodes a single-pass 46-kDa transmembrane protein and is located on human chromosome11q12.2. Syt7 contains a single transmembrane domain, a variable linker sequence and C2A and C2B Ca2+-binding domains. It is ubiquitously expressed during development, but is later restricted to dividing cells, postmitotic neurons and neuroendocrine cells.
synthetic peptide corresponding to a sequence located near the C-terminus of human synaptotagmin 7 (Syt7), conjugated to KLH. The corresponding sequence is identical in rat and mouse Syt7.
Anti-Synaptotagmin 7 (C-terminal) antibody produced in rabbit has been used in immunoblotting (~45 kDa).
Biochem/physiol Actions
Synaptotagmin7 (SYT7) helps to facilitate the calciumdependent modulation of membrane trafficking during synaptic transmission. It has been proposed to regulate different types of Ca2+ -dependent exocytosis. Syt7 has been proposed to play a key role in the regulation of Ca2+- dependent lysosome exocytosis. Knockout of Syt7 in mice results in impaired insulin secretion and glucose intolerance.
Physical form
Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen ~45 kDa
species reactivity	human, mouse, rat
enhanced validation	recombinant expression
concentration	~1.5 mg/mL
application(s)	western blot: 2-4 µg/mL using mouse brain extracts (S1 fraction), rat brain extracts (S1 fraction) or HEK-293T cell lysates over expressing human synaptotagmin 7
conjugate	unconjugated
UniProt accession no.	O43581,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... SYT7(9066) mouse ... Syt7(54525) rat ... Syt7(59267)

RIDADR	NONH for all modes of transport
Flash Point F	Not applicable
Flash Point C	Not applicable