Arginase Activity Assay Kit MAK112-1KT

NACRES:

NA.84

Arginase is a manganese-containing enzyme that catalyzes the conversion of arginine to urea and ornithine. Two isoforms of arginase are present in most mammals which differ in their tissue distribution and subcellular localization. Arginase I is a cytoplasmic protein predominantly expressed in the liver where it catalyzes the fifth and final step of the Urea Cycle. Arginase II is a mitochondrial protein with broader tissue distribution whose function may include nitric oxide and polyamine metabolism. Decreased activity or expression of Arginase I results in the autosomal recessive disorder hyperarginemia. Increased serum Arginase activity is implicated in hepatic injury and in certain pathological conditions such as cancer. Arginase also participates in multiple inflammatory reactions in the immune system, such as macrophage-mediated cytotoxicity.
Arginase Activity Assay Kit has been used to assess the activity of arginase.
Compatible with high-throughput handling systems.
Suitable for the detection of arginase activity in enzyme preparations, serum, plasma, tissue culture, and similar samples. Suitable for studying the effects of drugs on arginase activity.
In this assay, arginase catalyzes the conversion of arginine to urea and ornithine. The urea produced specifically reacts with the substrate to generate a colored product, proportional to the arginase activity present.

usage	sufficient for 200 colorimetric tests
detection method	colorimetric
storage temp.	20°C
Gene Information	human ... ARG1(383), ARG2(384) mouse ... ARG1(11846), ARG2(11847) rat ... ARG2(29215), Arg1(29221)

pictograms	GHS05
signalword	Danger
hcodes	H290 - H314 - H412
pcodes	P234 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
RIDADR	UN 3316 9