Anti-Human IgM (-chain specific) antibody produced in rabbit I0140-2ML

MDL number:	MFCD00162459
NACRES:	NA.46

IgM is a class of antibodies containing a pentamer of five IgG equivalents with 10 Fab fragments, joined by a single cross-linking peptide (J-chain). It constitutes 15% of the normal adult immunoglobulins.
Specificity
The antibody preparation is specific for human IgM when tested against purified human IgA, IgG, IgM, Bence Jones kappa, and lambda myeloma proteins.
Anti-Human IgM (μ-chain specific) antibody produced in rabbit was used as secondary antibody in immunoblotting and indirect ELISA.
Biochem/physiol Actions
IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
Immunoglobulin M (IgM) antibodies appear early in the course of infections. IgM is an initial immunoglobulin produced in the developing fetus as a result of the immune response during the second trimester of pregnancy. It is then substituted by IgG. Therefore, the diagnosis of specific antibodies of the IgM class is useful in detecting chronic infections. IgM is essential for the fetal and neonatal host defense system. IgM cannot cross the placenta. Hence, the presence of IgM might indicate an intrauterine viral infection. IgM antibodies are responsible for the agglutination of red blood cells in mismatched blood transfusions. The level of IgM may vary with the status of disease or infection.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots at –20 °C. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
Quality Level	300,
antibody form	IgG fraction of antiserum
antibody product type	secondary antibodies
clone	polyclonal
form	buffered aqueous solution
application(s)	indirect ELISA: 1:100,000
conjugate	unconjugated
shipped in	dry ice
storage temp.	−20°C

WGK Germany	nwg
Flash Point F	Not applicable
Flash Point C	Not applicable