Sigma-Aldrich

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Quality Level	200,
biological source	synthetic
assay	≥98% (iodine, titration)
form	powder
solubility	water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
originator	Pfizer
SMILES string	NNCCC1=CC=CC=C1.OS(=O)(O)=O
InChI	1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)
InChI key	RXBKMJIPNDOHFR-UHFFFAOYSA-N
Gene Information	human ... MAOA(4128), MAOB(4129)

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.

pictograms	GHS06
signalword	Danger
hcodes	H301
pcodes	P301 + P310
Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves,
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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PNU-120596

Empirical Formula (Hill Notation):	C₁₃H₁₄ClN₃O₄
CAS Number:	501925-31-1
Molecular Weight:	311.72
MDL number:	MFCD00095313
PubChem Substance ID:	329819995
NACRES:	NA.77

Quality Level	100,
assay	≥98% (HPLC)
color	white to off-white
solubility	DMSO: >10 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	COc1cc(OC)c(NC(=O)Nc2cc(C)on2)cc1Cl
InChI	1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)
InChI key	CEIIEALEIHQDBX-UHFFFAOYSA-N

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PP1 is a pyrazolopyrimidine compound that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding. It also inhibits protein tyrosine kinase (PTK6) and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.
PP1 is a potent and selective Src family protein tyrosine kinase inhibitor.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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PP1

Empirical Formula (Hill Notation):	C₁₆H₁₉N₅
CAS Number:	172889-26-8
Molecular Weight:	281.36
MDL number:	MFCD01076570
PubChem Substance ID:	329819992
NACRES:	NA.77

PP1 has been used as:

an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn
a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth
a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)

Quality Level	100,
assay	≥98% (HPLC)
form	powder
color	white to off-white
solubility	DMSO: >20 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
InChI	1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChI key	ZVPDNRVYHLRXLX-UHFFFAOYSA-N

Packaging
5 mg in glass bottle
Biochem/physiol Actions
PP2 is a selective inhibitor of Src-family tyrosine kinases of non-receptor tyrosine kinases (nRTK). It shows >10,000-fold selectivity over Zeta-chain-associated protein kinase 70 (ZAP-70) and Janus kinase 2 (JAK2). PP2 effectively reduces cervical cancer proliferation in vitro and in vivo.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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PP2

Empirical Formula (Hill Notation):	C₁₅H₁₆ClN₅
CAS Number:	172889-27-9
Molecular Weight:	301.77
MDL number:	MFCD01568210
PubChem Substance ID:	329819994
NACRES:	NA.77

to analyze the effects of Src/focal adhesion kinase (FAK) signaling on IQ domain GTPase-activating protein 1 (IQGAP1)-mediated anoikis resistance
for Src inhibition to study its effect on epidermal growth factor receptor (EGFR) and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation in non-small cell lung cancer (NSCLC) cells
for pharmacological inhibition of SRC in MDA-MB-231 breast cancer cells

Quality Level	100,
assay	≥98% (HPLC)
form	powder
color	white to off-white
solubility	DMSO: >10 mg/mL
originator	Pfizer
storage temp.	2-8°C
SMILES string	CC(C)(C)n1nc(-c2ccc(Cl)cc2)c3c(N)ncnc13
InChI	1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChI key	PBBRWFOVCUAONR-UHFFFAOYSA-N

Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.

pictograms	GHS06
signalword	Danger
hcodes	H301
pcodes	P301 + P310
RIDADR	UN 2811 6.1 / PGIII
Flash Point F	Not applicable
Flash Point C	Not applicable

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Prazosin hydrochloride

Empirical Formula (Hill Notation):	C₁₉H₂₁N₅O₄ · HCl
CAS Number:	19237-84-4
Molecular Weight:	419.86
Beilstein/REAXYS Number:	4303561
EC Number:	242-903-4
MDL number:	MFCD00058177
PubChem Substance ID:	24277793
NACRES:	NA.77

Prazosin hydrochloride has been used:

to block the 1adrenergic receptors that mediate sympathetic vasoconstriction in mice
as an 1-adrenoceptor blocker,administered intragastrically in rats
as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions

Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.

This compound is featured on the 1-Adrenoceptors, 2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Bottomless glass bottle. Contents are inside inserted fused cone.

Caution

Hygroscopic; light sensitive.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Quality Level	100
assay	99.0% (HPLC)
solubility	H₂O: 0.5 mg/mL, methanol: 6 mg/mL, dilute aqueous acid: insoluble
originator	Pfizer
SMILES string	Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
InChI	1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
InChI key	WFXFYZULCQKPIP-UHFFFAOYSA-N
Gene Information	human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Prinomastat comprises hydroxamic acid group and chelates with zinc ion.

pictograms	GHS07,GHS08
signalword	Warning
hcodes	H336 - H361fd - H373
pcodes	P201 - P202 - P260 - P271 - P280 - P308 + P313
Target Organs	Central nervous system
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Prinomastat hydrochloride

Empirical Formula (Hill Notation):	C₁₈H₂₁N₃O₅S₂ · HCl
CAS Number:	192329-42-3
Molecular Weight:	459.97
PubChem Substance ID:	329823770
NACRES:	NA.77

Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samples and mouse embryo cultures. It may be used as a MMP-2 inhibitor in HepG2 cells.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. It is extremely potent at MMP-3 and MMP-2 with IC50s, 30 pM & 50 pM, respectively.

This compound was developed by Pfizer for Cytoskeleton & Extracellular Matrix research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	95% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to beige
solubility	H₂O: 15 mg/mL (clear solution)
originator	Pfizer
storage temp.	room temp
SMILES string	Cl.CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c2ccc(Oc3ccncc3)cc2
InChI	1S/C18H21N3O5S2.ClH/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14;/h3-10,16,23H,11-12H2,1-2H3,(H,20,22);1H/t16-;/m0./s1
InChI key	UQGWXXLNXBRNBU-NTISSMGPSA-N

Procaterol is used to prevent lung fibroblast migration. It has anti-inflammatory properties. It can block type 2 T helper (Th2)-related chemokine production in human monocytes and bronchial epithelial cells.
Biochem/physiol Actions
2-adrenoceptor agonist; bronchodilator.
Features and Benefits
This compound is featured on the -Adrenoceptors, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms	GHS08
signalword	Danger
hcodes	H360
pcodes	P201 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Procaterol hydrochloride

Empirical Formula (Hill Notation):	C₁₆H₂₂N₂O₃ · HCl
CAS Number:	62929-91-3
Molecular Weight:	326.82
EC Number:	263-763-0
MDL number:	MFCD04221378
PubChem Substance ID:	24899017
NACRES:	NA.77

Quality Level	200,
originator	Pfizer
storage temp.	2-8°C
SMILES string	Cl.CC[C@H](NC(C)C)[C@H](O)c1ccc(O)c2NC(=O)C=Cc12
InChI	1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H/t12-,16+;/m0./s1
InChI key	AEQDBKHAAWUCMT-CVHDTDHSSA-N

Pyrvinium pamoate salt hydrate has been used as an activator of casein kinase 1α (CK1α) in terminal blast phase of chronic myeloid leukemia (BP-CML) and human embryonic kidney (HEK293) cells. It has also been used as an inhibitor of β-catenin in Wilms tumor
Packaging
10, 50 mg in glass bottle
Biochem/physiol Actions
Pyrvinium pamoate is a potent androgen receptor inhibitor. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors that reside in the cytoplasm and activated by testosterone and dihydrotestosterone. AR inhibitors have potential therapeutic benefit in prostate cancer; competitive inhibitors and chemical castration methods have been discovered, but both therapies have undesirable side effects and/or resistance potential. A screen for non-competitive inhibitors was performed, resulting in the discovery of pyrvinium as an AR inhibitor. In comparison to competitive inhibitors, this compound does not bind to the ligand-binding domain of AR or block DNA occupancy by AR, but it inhibits AR-dependent gene expression via a distinct signaling mechanism. It is more potent than classical competitive AR antagonists and exhibits synergy with other AR inhibitors.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is featured on the Nuclear Receptors (Steroids), page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Pyrvinium pamoate salt hydrate

Empirical Formula (Hill Notation):	C₂₆H₂₈N₃· 0.5 C₂₃H₁₄O₆ · xH₂O
CAS Number:	3546-41-6
Molecular Weight:	575.70 (anhydrous basis)
PubChem Substance ID:	329819982

Quality Level	100,
assay	≥98% (HPLC)
form	powder
color	red
solubility	DMSO: >10 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	O.CN(C)c1ccc2[n+](C)c(\C=C\c3cc(C)n(c3C)-c4ccccc4)ccc2c1.CN(C)c5ccc6[n+](C)c(\C=C\c7cc(C)n(c7C)-c8ccccc8)ccc6c5.Oc9c(cc%10ccccc%10c9Cc%11c(O)c(cc%12ccccc%11%12)C([O-])=O)C([O-])=O
InChI	1S/2C26H28N3.C23H16O6.H2O/c21-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5;24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;/h26-18H,1-5H3;1-10,24-25H,11H2,(H,26,27)(H,28,29);1H2/q2*+1;;/p-2
InChI key	FGNOZQNUEDSSTR-UHFFFAOYSA-L

Quinapril hydrochloride has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on renal tubular epithelial cell proliferation in human renal tubular epithelial cells. It has also been used as an ACE inhibitor to evaluate its effects on the expression of angiotensin II (AII) in patient-derived Atheroma samples.
Packaging
250, 500 mg in glass bottle
Biochem/physiol Actions
Quinapril has been studied to exhibit therapeutic effects against hypertension and congestive heart failure.
Quinapril is a short-acting angiotensin converting enzyme (ACE) inhibitor.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.

pictograms	GHS07,GHS08
signalword	Warning
hcodes	H302 + H312 + H332 - H315 - H319 - H335 - H351
pcodes	P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Target Organs	Respiratory system
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Quinapril hydrochloride

Empirical Formula (Hill Notation):	C₂₅H₃₀N₂O₅ · HCl
CAS Number:	82586-55-8
Molecular Weight:	474.98
MDL number:	MFCD00889215
PubChem Substance ID:	329823858
NACRES:	NA.77

Quality Level	100,
assay	98% (HPLC)
form	solid
color	white
solubility	H₂O: >10 mg/mL
originator	Pfizer
storage temp.	2-8°C
SMILES string	Cl.CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2Cc3ccccc3C[C@H]2C(O)=O
InChI	1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1
InChI key	IBBLRJGOOANPTQ-JKVLGAQCSA-N
Gene Information	human ... ACE(1636)

Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Rapamycin

Empirical Formula (Hill Notation):	C₅₁H₇₉NO₁₃
Molecular Weight:	914.17
EC Number:	200-664-3
NACRES:	NA.77

R8781-200UL

R8781-200UL-PW

Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.

This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

200uL

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Is Hygroscopic.
Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal.

Quality Level	300
biological source	Streptomyces hygroscopicus
vapor pressure	0.56 hPa ( 20 °C)
sterility	0.2 µm filtered
assay	95% (HPLC)
form	solution
autoignition temp.	301 °C
concentration	2.5 mg/mL in DMSO (2.74 mM)
color	colorless to yellow
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	fungi, yeast
originator	Pfizer
storage temp.	20°C

Chemical structure: macrolide

Personal Protective Equipment	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
RIDADR	NA 1993 / PGIII
WGK Germany	WGK 1
Flash Point F	188.6 °F - closed cup
Flash Point C	87 °C - closed cup

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Rapamycin from Streptomyces hygroscopicus

Empirical Formula (Hill Notation):	C₅₁H₇₉NO₁₃
CAS Number:	53123-88-9
Molecular Weight:	914.17
MDL number:	MFCD00867594
PubChem Substance ID:	57654583
NACRES:	NA.77

1 mg in glass bottle

A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Quality Level	300
assay	95% (HPLC)
form	powder
color	off-white
solubility	ethanol: 2 mM, DMSO: soluble
Mode of action	enzyme \| inhibits, protein synthesis \| interferes
antibiotic activity spectrum	fungi, yeast
originator	Pfizer
storage temp.	20°C
SMILES string	CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
InChI	1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI key	QFJCIRLUMZQUOT-HPLJOQBZSA-N
Gene Information	human ... FKBP1A(2280)

pictograms	GHS08
signalword	Warning
hcodes	H351 - H361fd
pcodes	P201 - P202 - P280 - P308 + P313 - P405 - P501
Personal Protective Equipment	Eyeshields, Gloves, type N95 (US)
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2

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Rucaparib camsylate

Empirical Formula (Hill Notation):	C₁₉H₁₈FN₃O · C₁₀H₁₆O₄S
CAS Number:	1859053-21-6
Molecular Weight:	555.66
NACRES:	NA.77

Biochem/physiol Actions
Rucaparib is an inhibitor of the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It has been found to have anticancer activity in a number of cancers and has been approved for treatment of previously treated, BRCA-mutant ovarian cancer.

PZ0036-5MG

PZ0036-25MG

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	pale yellow
solubility	DMSO: 2 mg/mL, clear
originator	Pfizer
shipped in	dry ice
storage temp.	20°C
SMILES string	FC1=CC(C(NCC2)=O)=C3C2=C(C4=CC=C(CNC)C=C4)NC3=C1.CC5(C)[C@@H]6CC[C@@]5(CS(O)(=O)=O)C(C6)=O

Rupintrivir is an irreversible peptidomimetic inhibitor designed to target human rhinovirus (HRV). It was previously named as AG7088. It has been suggested that rupintrivir may be involved in vitro antiviral activity.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Rupintrivir (AG7088) is an irreversible human rhinovirus (HRV) 3C protease inhibitor, also found to inhibit enterovirus and norovirus.

pictograms	GHS08
signalword	Warning
hcodes	H361
pcodes	P280
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Rupintrivir

Empirical Formula (Hill Notation):	C₃₁H₃₉FN₄O₇
CAS Number:	223537-30-2
Molecular Weight:	598.66
NACRES:	NA.77

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
optical activity	[]/D +30 to +40°, c = 0.5 in chloroform-d
Торговая марка	Pfizer^®
color	white to beige
solubility	DMSO: 25 mg/mL, clear
originator	Pfizer
storage temp.	room temp
InChI	1S/C31H39FN4O7/c1-5-42-27(38)11-10-24(16-21-12-13-33-29(21)39)34-30(40)22(15-20-6-8-23(32)9-7-20)17-26(37)28(18(2)3)35-31(41)25-14-19(4)43-36-25/h6-11,14,18,21-22,24,28H,5,12-13,15-17H2,1-4H3,(H,33,39)(H,34,40)(H,35,41)/b11-10+/t21-,22+,24+,28-/m0/s1
InChI key	CAYJBRBGZBCZKO-BHGBQCOSSA-N

Packaging
10 mg in glass bottle
Biochem/physiol Actions
S-(+)-PD 123177 is selective AT2 angiotensin receptor antagonist. The angiotensin AT2 receptor is an atypical seven transmembrane domain receptor that is coupled to activation of tyrosine phosphatase and inhibition of MAP kinase, and does not undergo agonist-induced internalization. An investigation of the occurrence and nature of AT2 receptor phosphorylation revealed that phorbol ester-induced activation of protein kinase C (PKC) in HA-AT2 receptor-expressing COS-7 cells caused rapid and specific phosphorylation of a single residue (Ser354) located in the cytoplasmic tail of the receptor. Agonist activation of AT2 receptors by angiotensin II (Ang II) also caused rapid PKC-dependent phosphorylation of Ser354 that was prevented by the AT2 antagonist, S-(+)-PD 123177, and by inhibitors of PKC. In cells coexpressing AT1 and AT2 receptors, Ang II-induced phosphorylation of the AT2 receptor was reduced by S-(+)-PD 123177 and abolished by treatment with both antagonists or with PKC inhibitors. These findings indicate that the AT2 receptor is rapidly phosphorylated via PKC during homologous activation by Ang II, and also undergoes heterologous PKC-dependent phosphorylation during activation of the AT1 receptor.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is featured on the Angiotensin Receptors, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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S-(+)-PD 123177 trifluoroacetate salt hydrate P5749-10MG

Empirical Formula (Hill Notation):	C₂₉H₂₈N₄O₃ · xC₂HF₃O₂ · yH₂O
Molecular Weight:	480.56 (anhydrous free base basis)
MDL number:	MFCD09265257
PubChem Substance ID:	24724581
NACRES:	NA.77

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Quality Level	100,
assay	98% (HPLC)
form	solid
color	white to off-white
solubility	H₂O: >5 mg/mL
originator	Pfizer
storage temp.	2-8°C
SMILES string	O.OC(=O)C(F)(F)F.Cc1cc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c4ccccc4)c5ccccc5)ccc1N
InChI	1S/C29H28N4O3.C2HF3O2.H2O/c1-19-14-20(12-13-23(19)30)16-32-18-31-24-17-33(26(29(35)36)15-25(24)32)28(34)27(21-8-4-2-5-9-21)22-10-6-3-7-11-22;3-2(4,5)1(6)7;/h2-14,18,26-27H,15-17,30H2,1H3,(H,35,36);(H,6,7);1H2/t26-;;/m0../s1
InChI key	IRRZMYRIDIBBQG-ROPHLPQBSA-N

SC-236 has been used as a COX-2 inhibitor to study its effects on the mechano-reflex in rats.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
SC-236 exhibits anti-tumor activity in gastric cancer cells by modulating activator protein-1 (AP-1) expression and by blocking the anchorage-independent cell growth. It also exhibits a protective effect against cartilage damage by minimizing the inflammation and pain in osteoarthritis. It is also reported to treat allergic inflammation.
SC-236 is a cyclooxygenase-2 (COX-2) inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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SC-236

Empirical Formula (Hill Notation):	C₁₆H₁₁ClF₃N₃O₂S
CAS Number:	170569-86-5
Molecular Weight:	401.79
MDL number:	MFCD00941297
PubChem Substance ID:	329823698
NACRES:	NA.77

This compound was developed by Pfizer for Lipid Signaling research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to off-white
solubility	DMSO: >20 mg/mL
originator	Pfizer
storage temp.	2-8°C
SMILES string	NS(=O)(=O)c1ccc(cc1)-n2nc(cc2-c3ccc(Cl)cc3)C(F)(F)F
InChI	1S/C16H11ClF3N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25)
InChI key	NSQNZEUFHPTJME-UHFFFAOYSA-N

pictograms	GHS06
signalword	Danger
hcodes	H301
pcodes	P301 + P310
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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SC-51089 hydrate

Empirical Formula (Hill Notation):	C₂₂H₁₉ClN₄O₃·HCl · xH₂O
Molecular Weight:	459.33 (anhydrous basis)
MDL number:	MFCD17215974
PubChem Substance ID:	329823723
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
SC-51089 is a selective EP1 prostanoid receptor antagonist.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.

PZ0138-25MG

PZ0138-5MG

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to off-white
solubility	DMSO: 10 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	O.Cl.Clc1ccc2Oc3ccccc3CN(C(=O)NNC(=O)CCc4ccncc4)c2c1
InChI	1S/C22H19ClN4O3.ClH.H2O/c23-17-6-7-20-18(13-17)27(14-16-3-1-2-4-19(16)30-20)22(29)26-25-21(28)8-5-15-9-11-24-12-10-15;;/h1-4,6-7,9-13H,5,8,14H2,(H,25,28)(H,26,29);1H;1H2
InChI key	UEAWIGPAXPGSJC-UHFFFAOYSA-N

pictograms	GHS06
signalword	Danger
hcodes	H301 - H315 - H319 - H335
pcodes	P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
Target Organs	Respiratory system
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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SC-51322

Empirical Formula (Hill Notation):	C₂₂H₂₀ClN₃O₄S
CAS Number:	146032-79-3
Molecular Weight:	457.93
MDL number:	MFCD00916246
PubChem Substance ID:	329823719
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
SC-51322 is a selective EP1 prostanoid receptor antagonist.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the Prostanoid Receptors, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.

PZ0132-5MG

PZ0132-25MG

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to off-white
solubility	DMSO: 10 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	Clc1ccc2Oc3ccccc3CN(C(=O)NNC(=O)CCSCc4ccco4)c2c1
InChI	1S/C22H20ClN3O4S/c23-16-7-8-20-18(12-16)26(13-15-4-1-2-6-19(15)30-20)22(28)25-24-21(27)9-11-31-14-17-5-3-10-29-17/h1-8,10,12H,9,11,13-14H2,(H,24,27)(H,25,28)
InChI key	CQBVTZDISUKDSX-UHFFFAOYSA-N

pictograms	GHS06
signalword	Danger
hcodes	H301
pcodes	P301 + P310
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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SC-57461A

Empirical Formula (Hill Notation):	C₂₀H₂₅NO₃ · HCl
CAS Number:	423169-68-0
Molecular Weight:	363.88
MDL number:	MFCD00951253
PubChem Substance ID:	329823702
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
SC-57461A is an inhibitor of leukotriene A4 hydrolase.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.

PZ0110-5MG

PZ0110-25MG

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to off-white
solubility	DMSO: >5 mg/mL
originator	Pfizer
storage temp.	2-8°C
SMILES string	Cl.CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(O)=O
InChI	1S/C20H25NO3.ClH/c1-21(14-12-20(22)23)13-5-15-24-19-10-8-18(9-11-19)16-17-6-3-2-4-7-17;/h2-4,6-11H,5,12-16H2,1H3,(H,22,23);1H
InChI key	SBBJJLDNKNNWFJ-UHFFFAOYSA-N

pictograms	GHS07
signalword	Warning
hcodes	H302 - H315 - H319
pcodes	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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SC-58125

Empirical Formula (Hill Notation):	C₁₇H₁₂N₂SO₂F₄
CAS Number:	162054-19-5
Molecular Weight:	384.35
MDL number:	MFCD00930300
PubChem Substance ID:	329823724
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.

PZ0139-5MG

PZ0139-25MG

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to off-white
solubility	DMSO: 20 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	CS(=O)(=O)c1ccc(cc1)-n2nc(cc2-c3ccc(F)cc3)C(F)(F)F
InChI	1S/C17H12F4N2O2S/c1-26(24,25)14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
InChI key	JHBIMJKLBUMNAU-UHFFFAOYSA-N

The effect of exposure of sertraline hydrochloride was studied in chronically prepared ovine fetus. It was used in glucocorticoid function assay to study the effect of antidepressants on glucocorticoid receptor function in humans.
Packaging
10, 50 mg in glass bottle
Biochem/physiol Actions
Sertraline suppresses platelet function and exhibits antiplatelet and endothelium protective functions. It relieves depression and improves the quality of life in patients with cardiovascular disorders. It can also be prescribed to treat depression in Parkinson′s disease.
Selective serotonin reuptake inhibitor, antidepressant.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here, to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is featured on the Biogenic Amine Transporters, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Sertraline hydrochloride

Empirical Formula (Hill Notation):	C₁₇H₁₇NCl₂ · HCl
CAS Number:	79559-97-0
Molecular Weight:	342.69
MDL number:	MFCD00895772
PubChem Substance ID:	24278601
NACRES:	NA.77

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Quality Level	100,
assay	≥98% (HPLC)
form	powder
optical activity	[α]/D +33 to +43°, c = 2.0 in methanol
color	white
solubility	DMSO: >20 mg/mL
originator	Pfizer
SMILES string	ClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
InChI	1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI key	BLFQGGGGFNSJKA-XHXSRVRCSA-N
Gene Information	human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

pictograms	GHS07,GHS09
signalword	Warning
hcodes	H302 - H400
pcodes	P273 - P301 + P312 + P330
Personal Protective Equipment	Eyeshields,, Gloves,, type N95 (US),
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Sitaxentan sodium salt

Empirical Formula (Hill Notation):	C₁₈H₁₄ClN₂NaO₆S₂
CAS Number:	210421-74-2
Molecular Weight:	476.89
PubChem Substance ID:	329823772
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Sitaxentan (Sitaxsentan) is a potent and selective endothelin ET(A) receptor antagonist once used in the treatment of pulmonary arterial hypertension (PAH), but removed from the market because of hepatotoxicity. It is over 6000-fold selective for the the ETA receptor subtype with an IC50 of 1 nM for ETA versus an IC50 of 9800 nM for ETB.
Sitaxsentan prevents shunt mediated elevation of pulmonary vascular resistance (PVR). Sitaxsentan effectively inhibits basolateral Na+-taurocholate cotransporting polypeptide (NTCP), organic anion-transporting polypeptides (OATPs) and bile salt export pump (BSEP).

PZ0203-25MG

PZ0203-5MG

This compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to beige
solubility	H₂O: 10 mg/mL (clear solution)
originator	Pfizer
storage temp.	room temp
SMILES string	[Na+].Cc1cc2OCOc2cc1CC(=O)c3sccc3S(=O)(=O)[N-]c4onc(C)c4Cl
InChI	1S/C18H14ClN2O6S2.Na/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18;/h3-5,7H,6,8H2,1-2H3;/q-1;+1
InChI key	MDTNUYUCUYPIHE-UHFFFAOYSA-N
Gene Information	human ... EDNRA(1909), EDNRB(1910)

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Sonepiprazole hydrate

Empirical Formula (Hill Notation):	C₂₁H₂₇N₃O₃S · xH₂O
CAS Number:	170858-33-0
Molecular Weight:	401.52 (anhydrous basis)
MDL number:	MFCD05662325
PubChem Substance ID:	329823748
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Sonepiprazole (U-101387) is a selective D4 dopamine antagonist. Ki = 10 nM for the dopamine D4.2 receptor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the Dopamine Receptors, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.

PZ0174-5MG

PZ0174-25MG

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
storage condition	desiccated
color	white to off-white
solubility	DMSO: >10 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	NS(=O)(=O)c1ccc(cc1)N2CCN(CC[C@@H]3OCCc4ccccc34)CC2
InChI	1S/C21H27N3O3S/c22-28(25,26)19-7-5-18(6-8-19)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-27-21/h1-8,21H,9-16H2,(H2,22,25,26)/t21-/m0/s1
InChI key	WNUQCGWXPNGORO-NRFANRHFSA-N

Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.
Sorbinil may be used in cell signaling and neuroscience studies.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.
Sorbinil is an inhibitor of Aldose Reductase (AR). AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is featured on the Dopamine and Norepinephrine Metabolism, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Sorbinil

Empirical Formula (Hill Notation):	C₁₁H₉FN₂O₃
CAS Number:	68367-52-2
Molecular Weight:	236.20
MDL number:	MFCD00867380
PubChem Substance ID:	329824587
NACRES:	NA.77

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Quality Level	100,
assay	≥98% (HPLC)
form	powder
optical activity	[α]/D +50 to +60°, c = 1 in methanol
color	white to off-white
solubility	DMSO: ≥20 mg/mL
originator	Pfizer
storage temp.	2-8°C
SMILES string	Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1
InChI	1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
InChI key	LXANPKRCLVQAOG-NSHDSACASA-N

Spironolactone was added to rat diet to study the effect of long-term spironolactone use on renal function.

pictograms	GHS07
signalword	Warning
hcodes	H302
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Spironolactone

Empirical Formula (Hill Notation):	C₂₄H₃₂O₄S
CAS Number:	52-01-7
Molecular Weight:	416.57
EC Number:	200-133-6
MDL number:	MFCD00082250
PubChem Substance ID:	24277736
NACRES:	NA.77

1, 5 g in glass bottle

Spironolactone reduces aldosterone-induced potassium/magnesium loss and myocardial fibrosis. It reduces hypertension, improves the endothelial function and reduces the overall morbidity and mortality in patients with chronic heart failure. Spironolactone improves nitric oxide bioactivity and vascular endothelial vasodilator dysfunction.
Spironolactone is a competitive aldosterone receptor antagonist. Used as potassium sparing diuretic.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Spironolactone yields clear, faint yellow solution in chloroform at 50 mg/ml.

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. S3378.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Quality Level	200
assay	97.0-103.0%
mp	207-208 °C (lit.)
solubility	chloroform: complete 50 mg/ml, clear, faintly yellow
originator	Pfizer
SMILES string	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]45CCC(=O)O5)[C@H]13
InChI	1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
InChI key	LXMSZDCAJNLERA-ZHYRCANASA-N
Gene Information	human ... HSD17B1(3292), NR3C2(4306) rat ... Ar(24208)

Streptozocin or streptozotocin, is obtained from Streptomyces achromogenes. Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing -cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.

pictograms	GHS08
signalword	Danger
hcodes	H360FD
pcodes	P201 - P202 - P280 - P308 + P313 - P405 - P501
Personal Protective Equipment	Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

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Streptozocin

Empirical Formula (Hill Notation):	C₈H₁₅N₃O₇
CAS Number:	18883-66-4
Molecular Weight:	265.22
Beilstein/REAXYS Number:	2060675
EC Number:	242-646-8
MDL number:	MFCD00006607
PubChem Substance ID:	57654595
NACRES:	NA.77

Streptozocin or streptozotocin is used to induce type 1 diabetes for medical research.

50, 100, 500 mg in glass bottle
1, 5 g in glass bottle

An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
Clinically, the chemical is used for the treatment of pancreatic β cell carcinoma.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Mixed anomers

Quality Level	200
assay	75% -anomer basis, 98% (HPLC)
form	powder
color	white to light yellow
mp	121 °C (dec.) (lit.)
Mode of action	DNA synthesis \| interferes
antibiotic activity spectrum	neoplastics
originator	Pfizer
storage temp.	20°C
SMILES string	CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
InChI	1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
InChI key	ZSJLQEPLLKMAKR-GKHCUFPYSA-N

SU 516 was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain.3 It was used to study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension.4
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.1 It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.2
SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.

pictograms	GHS02,GHS08
signalword	Warning
hcodes	H228 - H341 - H351
pcodes	P201 - P202 - P210 - P240 - P241 - P308 + P313
Personal Protective Equipment	Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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SU 5416

Empirical Formula (Hill Notation):	C₁₅H₁₄N₂O
CAS Number:	204005-46-9
Molecular Weight:	238.28
MDL number:	MFCD01940922
PubChem Substance ID:	24278606
NACRES:	NA.77

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Quality Level	100,
assay	98% (HPLC)
form	powder
color	yellow to yellow-orange
mp	221-222 °C
solubility	DMSO: 20 mg/mL, clear (warmed), H₂O: insoluble
originator	Pfizer
storage temp.	20°C
SMILES string	Cc1cc(C)c(C=C2C(=O)Nc3ccccc23)[nH]1
InChI	1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8+
InChI key	WUWDLXZGHZSWQZ-XYOKQWHBSA-N
Gene Information	human ... EGFR(1956), FLT1(2321), IGFBP1(3484), IL2(3558), KDR(3791), PDGFRB(5159) mouse ... Flt1(14254), Kdr(16542)

Personal Protective Equipment	dust mask type N95 (US),, Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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SU5614

Empirical Formula (Hill Notation):	C₁₅H₁₃ClN₂O
CAS Number:	1055412-47-9
Molecular Weight:	272.73
MDL number:	MFCD08443928
PubChem Substance ID:	329823735
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
SU5614 is a FMS-like tyrosine kinase 3 (FLT3) inhibitor; selective inhibitor of VEGF and PDGF receptor tyrosine kinases.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the PDGFR, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.

PZ0150-5MG

PZ0150-25MG

This compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	orange
solubility	DMSO: 20 mg/mL
originator	Pfizer
storage temp.	2-8°C
SMILES string	Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(Cl)cc23)[nH]1
InChI	1S/C15H13ClN2O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,1-2H3,(H,18,19)/b12-7-
InChI key	XLBQNZICMYZIQT-GHXNOFRVSA-N

hcodes	H413
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Sulopenem

Empirical Formula (Hill Notation):	C₁₂H₁₅NO₅S₃
CAS Number:	120788-07-0
Molecular Weight:	349.45
NACRES:	NA.77

Biochem/physiol Actions
Sulopenem is an orally available penem antibiotic designed to treat Gram-negative multi-drug resistant infections. It can be administered as an intravenous preparation, and it is also orally available.
Sulopenem, formerly CP-70,429, is stable to renal dehydropeptidase I and hydrolytic activity of AmpC β-lactamases and extended-spectrum β-lactamases (ESBLs) that convey resistance to third-generation cephalosporins. This action of sulopenem helps to act against urgent drug-resistant antimicrobial threats, including ESBL-producing Enterobacteriaceae. Sulopenem is effective than ciprofloxacin for treating urogenital upper urinary tract infection (uUTI) in adult women due to quinolone non-susceptible pathogens.

PZ0042-5MG

PZ0042-25MG

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to beige
solubility	DMSO: 2 mg/mL, clear
originator	Pfizer
shipped in	dry ice
storage temp.	20°C
SMILES string	O=C(O)C1=C(S[C@@H]2C[S@+]([O-])CC2)S[C@@]3([H])N1C([C@]3([H])[C@H](O)C)=O
InChI	1S/C12H15NO5S3/c1-5(14)7-9(15)13-8(11(16)17)12(20-10(7)13)19-6-2-3-21(18)4-6/h5-7,10,14H,2-4H2,1H3,(H,16,17)/t5-,6?,7+,10-,21?/m1/s1
InChI key	FLSUCZWOEMTFAQ-JNCILSLHSA-N

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

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Sunepitron hydrochloride

Empirical Formula (Hill Notation):	C₁₇H₂₃N₅O₂ · HCl
CAS Number:	148408-65-5
Molecular Weight:	365.86
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Sunepitron hydrochloride is a combined serotonin 5-HT1A receptor agonist and α2-adrenergic receptor antagonist. Sunepitron hydrochloride has been tested for the treatment of depression and anxiety.

PZ0279-5MG

PZ0279-25MG

This compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

assay	98% (HPLC)
Quality Level	100,
form	powder
Торговая марка	Pfizer^®
color	white to beige
solubility	H₂O: 20 mg/mL, clear
originator	Pfizer
storage temp.	room temp
InChI	1S/C17H23N5O2.ClH/c23-15-4-5-16(24)22(15)11-13-2-3-14-12-21(9-8-20(14)10-13)17-18-6-1-7-19-17;/h1,6-7,13-14H,2-5,8-12H2;1H/t13-,14-;/m0./s1
InChI key	HWGPYTRJVVMHGT-IODNYQNNSA-N

Sunitinib malate has been used:

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Sunitinib malate

Empirical Formula (Hill Notation):	C₂₂H₂₇FN₄O₂ · C₄H₆O₅
CAS Number:	341031-54-7
Molecular Weight:	532.56
MDL number:	MFCD08282795
PubChem Substance ID:	329823681
NACRES:	NA.77

to study its mechanism in the inhibition of MCF-7 cell migration and angiogenesis
as a reference molecule to compare its docking energies with other ligands/vascular endothelial growth factor receptor (VEGF) receptor blocker
used in proliferation assay

5, 25 mg in glass bottle

Sunitinib has greater bioavailability and potency compared to other inhibitors. It prevents angiogenesis.
Sunitinib malate is a receptor tyrosine kinase inhibitor, which targets VEGF-R1, VEGF-R2, VEGF-R3, PDGF-Rα, PDGF-Rβ, KIT, FLT3, CSF-1R, and RET. Sunitinib malate is an anticancer drug.

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
solubility	DMSO: >10 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	O[C@@H](CC(O)=O)C(O)=O.CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
InChI	1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1
InChI key	LBWFXVZLPYTWQI-IPOVEDGCSA-N
Gene Information	human ... CSF1R(1436), FLT1(2321), FLT3(2322), FLT4(2324), KDR(3791), KIT(3815), PDGFRA(5156), PDGFRB(5159), RET(5979)

pictograms	GHS08
signalword	Danger
hcodes	H360 - H372
pcodes	P201 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Sutezolid

Empirical Formula (Hill Notation):	C₁₆H₂₀FN₃O₃S
CAS Number:	168828-58-8
Molecular Weight:	353.41
MDL number:	MFCD00937821
PubChem Substance ID:	329823692

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Sutezolid (PNU 100480) is an oxazolidinone antimicrobial. Sutezolid inhibits protein synthesis by inhibiting bacterial mRNA translation. Sutezolid is being investigated for the treatment of multiple drug–resistant and extensively drug-resistant tuberculosis. The compound is a less toxic and more potent derivative of linezolid.

PZ0035-5MG

PZ0035-25MG

This compound was developed by Pfizer for Immunology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
optical activity	[]/D -8 to -12°, c = 1 in chloroform-d
Торговая марка	Pfizer^®
color	white to beige
solubility	DMSO: 20 mg/mL, clear
originator	Pfizer
storage temp.	room temp
SMILES string	FC1=CC(N(C[C@H](CNC(C)=O)O2)C2=O)=CC=C1N3CCSCC3
InChI	1S/C16H20FN3O3S/c1-11(21)18-9-13-10-20(16(22)23-13)12-2-3-15(14(17)8-12)19-4-6-24-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
InChI key	FNDDDNOJWPQCBZ-ZDUSSCGKSA-N

Temsirolimus is an esterified rapamycin compound, soluble in water.

pictograms	GHS07
signalword	Warning
hcodes	H302
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Temsirolimus

Empirical Formula (Hill Notation):	C₅₆H₈₇NO₁₆
CAS Number:	162635-04-3
Molecular Weight:	1030.29
MDL number:	MFCD00934421
PubChem Substance ID:	329823687
NACRES:	NA.77

Temsirolimus has been used:

in combination with radiation to study its effect on von Hippel Lindau (VHL) tumour suppressor gene-deficient renal carcinoma cell lines
to induce autophagy
as a mammalian target of rapamycin complex 1 (mTORC1) inhibitor to study the effect of cellular Akt-kinase on human papillomaviruses 16 (HPV16) late gene expression

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Temsirolimus is a specific inhibitor of mammalian target of rapamycin (mTOR) mTOR Complex 1 (mTORC1). Temsirolimus is an antiproliferative and antiangiogenic, the first-in-class mTOR inhibitor approved for the treatment of patients with advanced poor prognosis renal cell carcinoma.
The inhibitory action of temsirolimus is mediated by FKBP-12 (FK506-binding protein 12), a major intracellular protein. It is useful in treating renal-cell carcinoma.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the PKB/Akt, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to off-white
solubility	DMSO: 20 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	CO[C@@H]1CC(CC[C@H]1OC(=O)C(C)(CO)CO)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](CC3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC
InChI	1S/C56H87NO16/c1-33-17-13-12-14-18-34(2)45(68-9)29-41-22-20-39(7)56(67,73-41)51(63)52(64)57-24-16-15-19-42(57)53(65)71-46(30-43(60)35(3)26-38(6)49(62)50(70-11)48(61)37(5)25-33)36(4)27-40-21-23-44(47(28-40)69-10)72-54(66)55(8,31-58)32-59/h12-14,17-18,26,33,35-37,39-42,44-47,49-50,58-59,62,67H,15-16,19-25,27-32H2,1-11H3/b14-12+,17-13+,34-18+,38-26+/t33-,35-,36-,37-,39-,40+,41+,42+,44-,45+,46+,47-,49-,50+,56-/m1/s1
InChI key	CBPNZQVSJQDFBE-FUXHJELOSA-N
Gene Information	human ... FKBP1A(2280)

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tenidap

Empirical Formula (Hill Notation):	C₁₄H₉ClN₂O₃S
CAS Number:	120210-48-2
Molecular Weight:	320.75
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Tenidap is an anti-inflammatory and anti-rheumatic with a variety of activities. Tenidap preferentially inhibits COX-1 with an IC50 value of 30 nM, and also has some lesser inhibitory activity towards COX-2 and 5-lipoxygenase (IC50 values are 1.2 and > 30 µM for COX-2 and 5-lipoxygenase respectively). Tenidap is also a cytokine modulator, an opener of inward rectifying hKIR2.3 channels (EC50 = 402 nM) and has been shown to modulate cytoplasmic pH and inhibit anion transport in vitro.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.

PZ0196-5MG

PZ0196-25MG

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	97% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	faintly yellow to dark yellow
solubility	DMSO: 1 mg/mL, clear (warmed)
originator	Pfizer
storage temp.	2-8°C
InChI	1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20)
InChI key	IZSFDUMVCVVWKW-UHFFFAOYSA-N

Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.

pictograms	GHS07
signalword	Warning
hcodes	H302
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tigecycline hydrate

Empirical Formula (Hill Notation):	C₂₉H₃₉N₅O₈ · xH₂O
CAS Number:	1229002-07-6
Molecular Weight:	585.65 (anhydrous basis)
PubChem Substance ID:	329823688
NACRES:	NA.77

TIGECYCLINE HYDRATE has been used:

for antibiotic susceptibility testing
to study its effects on multiple nonsmall cell lung cancer (NSCLC) cell lines
to evaluate its effects on the binding of fluoroquinolones to human serum albumin
as a standard to investigate the penetration of tigecycline into cornea, aqueous humor and vitreous humor

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.

air sensitive
This compound was developed by Pfizer for Immunology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
optical activity	[]/D -175 to -205°, c = 0.15 in methanol
Торговая марка	Pfizer^®
color	off-white to yellow-brown
solubility	DMSO: 3 mg/mL (warmed)
originator	Pfizer
storage temp.	2-8°C
SMILES string	O.CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(cc(NC(=O)CNC(C)(C)C)c(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C
InChI	1S/C29H39N5O8.H2O/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36;/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35);1H2/t12-,14-,21-,29-;/m0./s1
InChI key	PMPLAEFBZIFHAR-KXLOKULZSA-N

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H319 - H360
pcodes	P201 - P202 - P264 - P280 - P305 + P351 + P338 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Tiplaxtinin

Empirical Formula (Hill Notation):	C₂₄H₁₆F₃NO₄
CAS Number:	393105-53-8
Molecular Weight:	439.38
MDL number:	MFCD09475615
PubChem Substance ID:	329823818
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Tiplaxtinin has high oral bioavailability. It is metabolically stable and shows large safety multiples in animal toxicology studies. Tiplaxtinin can be easily synthesized in bulk quantities. This drug also reduces diet-induced obesity in mice.
Tiplaxtinin is a potent and selective PAI-1 inhibitor. Tiplaxtinin demonstrated efficacy in vivo in multiple models of acute arterial thrombosis and has been shown to reduce physiologic PAI-1 activity.

PZ0295-5MG

PZ0295-25MG

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to beige
solubility	DMSO: 20 mg/mL, clear
originator	Pfizer
shipped in	wet ice
storage temp.	20°C
SMILES string	O=C(C(O)=O)C1=CN(CC2=CC=CC=C2)C3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C31
InChI	1S/C24H16F3NO4/c25-24(26,27)32-18-9-6-16(7-10-18)17-8-11-21-19(12-17)20(22(29)23(30)31)14-28(21)13-15-4-2-1-3-5-15/h1-12,14H,13H2,(H,30,31)
InChI key	ODXQFEWQSHNQNI-UHFFFAOYSA-N

hcodes	H413
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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TMI-1

Empirical Formula (Hill Notation):	C₁₇H₂₂N₂O₅S₂
CAS Number:	287403-39-8
Molecular Weight:	398.50
PubChem Substance ID:	329823847

Packaging
5 mg in glass bottle
Biochem/physiol Actions
TMI-1 (WAY-171318) is potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) also known as the tumor necrosis factor-α (TNF-α) converting enzyme (TACE), and matrix metalloprotease (MMP). TMI-1 potently inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines.

PZ0336-5MG

PZ0336-25MG

This compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to beige
solubility	DMSO: 25 mg/mL, clear
originator	Pfizer
storage temp.	room temp
SMILES string	O=S(N1[C@@H](C(NO)=O)C(C)(C)SCC1)(C2=CC=C(OCC#CC)C=C2)=O
InChI	1S/C17H22N2O5S2/c1-4-5-11-24-13-6-8-14(9-7-13)26(22,23)19-10-12-25-17(2,3)15(19)16(20)18-21/h6-9,15,21H,10-12H2,1-3H3,(H,18,20)/t15-/m0/s1
InChI key	CVZIHNYAZLXRRS-HNNXBMFYSA-N

Tofacitinib is a synthetic molecule corresponding to a molecular weight of 312.4 Da and is permeable by transcellular diffusion.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Toceranib

Empirical Formula (Hill Notation): C₂₂H₂₅FN₄O₂

CAS Number: 356068-94-5

Molecular Weight: 396.46

Кат. номер

PZ0338-5MG

PZ0338-25MG

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Toceranib (SU11654) is a protein tyrosine kinase inhibitor that selectively targets stem cell factor receptor c-kit, including all forms of mutant Kit, as well as PDGFR and VEGFR. Toceranib exhibited Ki values of 5 nM for PDGFR and 6 nM for VEGFR. Toceranib phosphate is approved for use in mast cell cancer in dogs.
Other Notes
This compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
Параметры

Quality Level 100,

assay 98% (HPLC)

form powder

Торговая марка Pfizer^®

color yellow to orange

solubility DMSO: 2 mg/mL, clear (warmed)

originator Pfizer

storage temp. room temp

Safety Information

pictograms GHS07

signalword Warning

hcodes H315 - H319

pcodes P305 + P351 + P338

RIDADR NONH for all modes of transport

WGK Germany WGK 3

Flash Point F Not applicable

Flash Point C Not applicable

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Tofacitinib citrate

Empirical Formula (Hill Notation):	C₁₆H₂₀N₆O · C₆H₈O₇
CAS Number:	540737-29-9
Molecular Weight:	504.49
MDL number:	MFCD11616529
PubChem Substance ID:	329823686
NACRES:	NA.77

Tofacitinib citrate has been used:

as a ligand for human serum albumin in fluorescence quenching, dynamic light scattering (DLS) measurements, differential scanning calorimetry and molecular docking studies
as a medium supplement for full depth articular cartilage (FDC) explants to monitor cytokine-induced proteoglycan loss
as a Janus kinase inhibitor in MCF7 breast cancer cells

5, 25 mg in glass bottle

Tofacitinib is a potent inhibitor of Janus kinase 3 (JAK3) with some JAK-1 inhibitory activity as well. It blocks downstream STAT signaling resulting in potent inhibition of inflammatory cytokines with resultant immunosuppressive and anti-inflammatory activity. Tofacitinib is being investigated for for several autoimmune disorders including, rheumatoid arthritis, psoriasis and dry eye.

Tofacitinib has been expertly reviewed and recommended by the Chemical Probes Portal. This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to beige
solubility	DMSO: 5 mg/mL (clear solution; warmed)
originator	Pfizer
storage temp.	room temp
SMILES string	OC(=O)CC(O)(CC(O)=O)C(O)=O.C[C@@H]1CCN(C[C@@H]1N(C)c2ncnc3[nH]ccc23)C(=O)CC#N
InChI	1S/C16H20N6O.C6H8O7/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t11-,13+;/m1./s1
InChI key	SYIKUFDOYJFGBQ-YLAFAASESA-N
Gene Information	human ... JAK1(3716), JAK2(3717), JAK3(3718), TYK2(7297)

Torcetrapib has been used as a reference standard in the medium chain-lipid based formulations.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Torcetrapib is a Cholesteryl ester transfer protein (CETP) inhibitor. CETP normally transfers cholesterol from HDL cholesterol to very low density or low density lipoproteins (VLDL or LDL). Inhibition of this process results in higher HDL levels (the "good" cholesterol-containing particle) and reduces LDL levels (the "bad" cholesterol). Unfortunately clinical trials were stopped because of excessive all cause mortality. Reasons are still being investigated, but may be related to some off target effects such as an increase in aldosterone secretion not found in some other CETP inhibitors.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Torcetrapib

Empirical Formula (Hill Notation):	C₂₆H₂₅F₉N₂O₄
CAS Number:	262352-17-0
Molecular Weight:	600.47
MDL number:	MFCD09260777
PubChem Substance ID:	329823744
NACRES:	NA.77

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
optical activity	[]/D >-70°
Торговая марка	Pfizer^®
color	white
solubility	DMSO: >5 mg/mL
originator	Pfizer
storage temp.	2-8°C
SMILES string	CCOC(=O)N1[C@H](CC)C[C@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)OC)c3cc(ccc13)C(F)(F)F
InChI	1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1
InChI key	CMSGWTNRGKRWGS-NQIIRXRSSA-N

Troglitazone is used to treat type 2 diabetes. It is associated with liver injury. Troglitazone functions as an inducer of cytochrome3A.

pictograms	GHS07
signalword	Warning
hcodes	H302
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Troglitazone T2573-5MG

Empirical Formula (Hill Notation):	C₂₄H₂₇NO₅S
CAS Number:	97322-87-7
Molecular Weight:	441.54
MDL number:	MFCD00878416
PubChem Substance ID:	24724629
NACRES:	NA.77

General description

Troglitazone has been used as a reagent in adipocyte differentiation medium.

5 mg in glass bottle

PPARγ agonist; anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity; induces apoptosis via a p53 pathway.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Nuclear Receptors (PPARs) and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Studies using troglitazone have reported that it can increase AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase in isolated rat extensor digitorum longus muscles1. Furthermore, analysis of troglitazone-mediated autophagy is reported to correlate with the stimulation of AMPK 2.

Quality Level	200
assay	≥98% (HPLC)
form	powder
color	white to off-white
solubility	DMSO: 20 mg/mL
originator	Pfizer
SMILES string	Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc3ccc(CC4SC(=O)NC4=O)cc3
InChI	1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
InChI key	GXPHKUHSUJUWKP-UHFFFAOYSA-N
Gene Information	human ... PPARA(5465), PPARG(5468)

Trovafloxacin mesylate has been used as a test compound in toxicity assay to assess its toxicity in 2D hepatocyte cultures. It has also been used to manipulate the mechanism of apoptotic cell disassembly during apoptosis.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Trovafloxacin mesylate acts as a pannexin1 (Panx1) inhibitor.
Trovafloxacin mesylate is a broad spectrum antibiotic. Trovafloxacin mesylate blocks the activity of DNA gyrase and topoisomerase IV, enzymes essential in the repliction, transcription, and repair of bacterial DNA.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.

Personal Protective Equipment	Eyeshields, Gloves, type N95 (US)
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	Not applicable
Flash Point C	Not applicable

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Trovafloxacin mesylate

Empirical Formula (Hill Notation):	C₂₀H₁₅F₃N₄O₃ · CH₃SO₃H
CAS Number:	147059-75-4
Molecular Weight:	512.46
MDL number:	MFCD00913361
PubChem Substance ID:	329823684
NACRES:	NA.77

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	>98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to off-white
solubility	DMSO: >10 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	CS(O)(=O)=O.NC1C2CN(CC12)c3nc4N(C=C(C(O)=O)C(=O)c4cc3F)c5ccc(F)cc5F
InChI	1S/C20H15F3N4O3.CH4O3S/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24;1-5(2,3)4/h1-4,7,10-11,16H,5-6,24H2,(H,29,30);1H3,(H,2,3,4)/t10-,11+,16+;
InChI key	DYNZICQDCVYXFW-AHZSKCOESA-N

UK-356618 has been used as a specific matrix metalloproteinase 3 (MMP3) inhibitor to study its effect on amitriptyline-induced glial cell line-derived neurotrophic factor (GDNF) mRNA expression and to confirm its influence on amitriptyline-induced zymographic MMP-9 activation in rat C6 astroglial cells.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
UK-356,618 is a potent, selective inhibitor of Matrix metalloproteinase MMP3 (stromelysin-1). MMP-3 IC50 = 5.9 nM, selectivity is 140-fold vs MMP-1, -2, -9, and -14.
UK 356618 has the potential to inhibit interleukin (IL)-6-induced cell migration in NCI H446 small cell lung cancer cells in vitro.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.

pictograms	GHS05,GHS08
signalword	Danger
hcodes	H314 - H361
pcodes	P201 - P260 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338
RIDADR	UN 1759 8 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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UK-356618

Empirical Formula (Hill Notation):	C₃₄H₄₃N₃O₄
CAS Number:	230961-08-7
Molecular Weight:	557.72
MDL number:	MFCD19443865
PubChem Substance ID:	329823737
NACRES:	NA.77

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
optical activity	[]/D >+25.0°, c = 0.5 in methanol
Торговая марка	Pfizer^®
color	white to tan
solubility	DMSO: 25 mg/mL
originator	Pfizer
storage temp.	2-8°C
SMILES string	C[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCc1ccc(c(C)c1)-c2ccccc2)CC(=O)NO)C(C)(C)C)c3ccccc3
InChI	1S/C34H43N3O4/c1-23-21-25(19-20-29(23)27-16-10-7-11-17-27)13-12-18-28(22-30(38)37-41)32(39)36-31(34(3,4)5)33(40)35-24(2)26-14-8-6-9-15-26/h6-11,14-17,19-21,24,28,31,41H,12-13,18,22H2,1-5H3,(H,35,40)(H,36,39)(H,37,38)/t24-,28-,31-/m1/s1
InChI key	JJHRUUKMPWUYIB-HVOSOHGQSA-N

pictograms	GHS07
signalword	Warning
hcodes	H302
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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UK-371,804 HCl

Empirical Formula (Hill Notation):	C₁₄H₁₆ClN₅O₄S · HCl
CAS Number:	256476-36-5
Molecular Weight:	422.29
NACRES:	NA.77

Biochem/physiol Actions
UK-371,804 is a reversible, substrate-competitive, highly potent (Ki = 10 nM) and selective urokinase-type plasminogen activator (uPA) Inhibitor with excellent selectivity over tPA, plasmin, Factor IXa and Xa. When applied topically, UK-371,80 effectively penetrates into excisional wounds of experimental pigs with no adverse effect on wound closure. UK-371,804 effectively blocks EGR-FMK from binding human uPA even in the presence of tissue proteins.

PZ0344-5MG

PZ0344-25MG

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to beige
solubility	DMSO: 10 mg/mL, clear (warmed)
originator	Pfizer
shipped in	dry ice
storage temp.	20°C
SMILES string	CC(C)(NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2NC(N)=N)=O)C(O)=O.[H]Cl

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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UK-383,367

Empirical Formula (Hill Notation):	C₁₅H₂₄N₄O₄
CAS Number:	348622-88-8
Molecular Weight:	324.38
MDL number:	MFCD19690945
PubChem Substance ID:	329823739
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
UK-383,367 is a procollagen C-proteinase (PCP) inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.

PZ0156-5MG

PZ0156-25MG

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
optical activity	[]/D 15°, c = 0.5 in methanol
Торговая марка	Pfizer^®
color	white to off-white
solubility	DMSO: >30 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	NC(=O)c1noc(n1)[C@H](CCCC2CCCCC2)CC(=O)NO
InChI	1S/C15H24N4O4/c16-13(21)14-17-15(23-19-14)11(9-12(20)18-22)8-4-7-10-5-2-1-3-6-10/h10-11,22H,1-9H2,(H2,16,21)(H,18,20)/t11-/m1/s1
InChI key	ARJCBSRIPGJMAD-LLVKDONJSA-N

pictograms	GHS06
signalword	Danger
hcodes	H301
pcodes	P301 + P310
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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UK-5099

Empirical Formula (Hill Notation):	C₁₈H₁₂N₂O₂
CAS Number:	56396-35-1
Molecular Weight:	288.30
MDL number:	MFCD19443867
PubChem Substance ID:	329823742
NACRES:	NA.77

UK-5099 has been used:

as a mitochondrial pyruvate blocker to reduce pyruvate transportation into mitochondria in Roswell park memorial institute (RPMI) 1640 medium for prostatic cancer cell line culture
in dimethyl sulfoxide (DMSO) stock, to study the effect of inhibiting pyruvate transport into mitochondria on pro-inflammatory responses in lipopolysaccharide activated macrophages
in topical treatment in order to study its effect on hair cycle induction in experimental mice

5, 25 mg in glass bottle

UK-5099 induces lactate generation.
UK-5099 is a potent inhibitor of the mitochondrial pyruvate transporter. In rat heart mitochondria, UK-5099 inhibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.

This compound was developed by Pfizer for Apoptosis & Cell Cycle research. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	yellow to tan
solubility	DMSO: >20 mg/mL
originator	Pfizer
storage temp.	2-8°C
SMILES string	OC(=O)\C(=C\c1cn(-c2ccccc2)c3ccccc13)C#N
InChI	1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
InChI key	BIZNHCWFGNKBBZ-JLHYYAGUSA-N

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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UK-59811 hydrochloride

Empirical Formula (Hill Notation):	C₂₂H₂₉BrN₂O₅ · HCl
Molecular Weight:	517.84
NACRES:	NA.77

Biochem/physiol Actions
UK-59811 is a 1,4-dihydropyridine calcium channel blocker. It has been used in a crystallographic and functional analysis of drug binding to the bacterial homotetrameric model voltage-gated calcium channel CaVAb, comparing 1,4-dihydropyridine binding to phenylalkylamine binding. UK-59811 inhibited CaVAb with an IC50 value of 194 nM, binding at the outer, lipid-facing surface of the pore at the interface between two CaVAb subunits, while at concentrations above 1 μM, it also bound in the pore. It was contrasted with phenylalkylamine Br-verapamil which binds on the intracellular side of the selectivity filter in the central cavity of the pore, physically blocking the pore.

PZ0353-25MG

PZ0353-5MG

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to beige
solubility	DMSO: 2 mg/mL, clear
originator	Pfizer
storage temp.	2-8°C
SMILES string	CCOC(C1=C(COCCN(C)C)NC(C)=C(C(OC)=O)C1C2=C(Br)C=CC=C2)=O

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

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UK-78282 monohydrochloride

Empirical Formula (Hill Notation):	C₂₉H₃₅NO₂HCl
CAS Number:	136647-02-4
Molecular Weight:	466.05
MDL number:	MFCD16875438
PubChem Substance ID:	329827628
NACRES:	NA.77

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is featured on the Potassium Channels, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
Preparation Note
UK-78282 monohydrochloride dissolves in DMSO at a concentration >10 mg/ml.

U3885-5MG

U3885-25MG

Quality Level	100,
assay	≥98% (HPLC)
form	solid
storage condition	desiccated
color	white to off-white
solubility	DMSO: >10 mg/mL
originator	Pfizer
shipped in	wet ice
storage temp.	−20°C
SMILES string	Cl.COc1ccc(CCCN2CCC(CC2)COC(c3ccccc3)c4ccccc4)cc1
InChI	1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H
InChI key	ZZSQARULZYQMIG-UHFFFAOYSA-N

Valdecoxib (VCX) is a diaryl substituted isoxazole compound. It comprises of sulfonyl propanamide and is a metabolite of parecoxib.

pictograms	GHS07,GHS09
signalword	Warning
hcodes	H319 - H400
pcodes	P273 - P305 + P351 + P338
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable

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Valdecoxib

Empirical Formula (Hill Notation):	C₁₆H₁₄N₂O₃S
CAS Number:	181695-72-7
Molecular Weight:	314.36
MDL number:	MFCD00950568
PubChem Substance ID:	329823753
NACRES:	NA.77

Valdecoxib may be used: as cyclooxygenase-2 (COX-2) inhibitor in fibroblast cells, as an analyte for mass spectrometry analysis, as an standard in ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for quantification of valdecoxib in plasma samples
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Valdecoxib is reported to elicit anti-inflammatory, analgesic and antipyretic functionality. It acts as a substrate for the liver enzyme cytochrome P450 2C9(CYP2C9) and cytochrome P450 3A4 (CYP3A4).
Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID), a cyclooxygenase-2 (COX-2) selective inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer^®
color	white to off-white
solubility	DMSO: >25 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	Cc1onc(-c2ccccc2)c1-c3ccc(cc3)S(N)(=O)=O
InChI	1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20)
InChI key	LNPDTQAFDNKSHK-UHFFFAOYSA-N
Gene Information	human ... PTGS2(5743)