Human -2 Microglobulin ELISA Kit RAB0024-1KT
The Human BDNF ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BDNF in serum, plasma, cell culture supernatants and urine.
β2-microglobulin (B2M) is a non-glycosylated polypeptide composed of 99 amino acids. It is present on the surface of all nucleated cells. The protein is characterized with a single polypeptide chain, which is linked noncovalently to major histocompatibility complex (MHC) class I cell surface antigen. The gene coding for B2M is mapped to human chromosome 15q.
Recombinant Human β-2-Microglobulin
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure ,(sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
β2-microglobulin (B2M) plays a vital role in cell survival, proliferation and metastasis in various types of cancer. Elevated concentration of β-2-microglobulin (B2M) can be considered as a prognostic marker for hemophagocytic lymphohistiocytosis (HLH). Elevated concentration of circulating B2M, due to renal dysfunction and long term hemodialysis, leads to dialysis-related amyloidosis. Overexpression of serum B2M is observed in hepatitis C virus (HCV) related chronic liver diseases, therefore it might act as a potential marker for the HCV disease progression towards cirrhosis and carcinoma. Missense mutation in the B2M gene results in familial hypercatabolic hypoproteinemia (FHH).
A sample Certificate of Analysis is available for this product.
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species reactivity | human |
packaging | kit of 96 wells (12 strips x 8 wells) |
application(s) | ELISA: suitable, capture ELISA: suitable |
input | sample type serum sample type urine sample type plasma sample type cell culture supernatant(s) |
assay range | inter-assay cv: <12% intra-assay cv: <10% sensitivity: 6 pg/mL standard curve range: 15.6-1000 pg/mL |
detection method | colorimetric |
shipped in | wet ice |
storage temp. | 20°C |
Gene Information | human ... B2M(567) |
pictograms | GHS05 |
signalword | Warning |
hcodes | H290 |
RIDADR | UN 3264 8 / PGIII |