Brain PI(4,5)P2

CAS Number:

383907-42-4

Кат. номер

840046P-10MG

840046P-5MG

840046P-25MG

840046P-1MG

Phosphatidylinositol 4,5-bisphosphate (PIP2) is synthesized from the precursor phosphatidylinositol 4-phosphate(PI4P). PIP2 is a phosphoinositide with three negative charges.
Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Brain PI(4,5)P2 has been used:

• in the preparation of Folch liposome
• in the preparation of giant unilamellar vesicles and multilamellar lipid sheets
• as a substrate for rubidium flux assay
• in the biochemical reaction assay mixture for various lipid kinases like Phosphatidylinositol-3-kinase gamma (PI3K), Phosphatidylinositol-3-kinase beta (PI3K), Phosphatidylinositol-3-kinase gamma (PI3K)

Phosphatidylinositol 4,5-bisphosphate (PIP2) is a signaling phospholipid, present in the plasma membrane. It acts as a precursor for inositide 3 phosphate, diacylglycerol. PIP2 is a gating ligand for most of the ion channels. It functions as an activatory ligand for eukaryotic inward rectifier potassium (Kir) channels.
5 mL Clear Glass Sealed Ampule (840046P-5mg)
5 mL Clear Glass Sealed Ampule (840046P-1mg)
5 mL Clear Glass Sealed Ampule (840046P-10mg)
5 mL Clear Glass Sealed Ampule (840046P-25mg)

assay	>99% (TLC)
form	powder
packaging	pkg of 1 x 1 mg (840046P-1mg), pkg of 1 x 10 mg (840046P-10mg), pkg of 1 x 25 mg (840046P-25mg), pkg of 1 x 5 mg (840046P-5mg)
Торговая марка	Avanti Polar Lipids
shipped in	dry ice
storage temp.	−20°C
SMILES string	[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](O)[C@H]1O)([O-])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3